Acamprol 333 mg: Effective Relief for Alcohol Dependence
| Product dosage: 333 mg | |||
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Synonyms | |||
Acamprol 333 mg is a prescription medication specifically formulated to support the maintenance of abstinence in alcohol-dependent patients. It functions by modulating neurotransmitter systems in the brain, helping to restore the chemical balance disrupted by chronic alcohol use. This medication is intended for use as part of a comprehensive treatment program that includes psychosocial support and counseling. Clinical studies have demonstrated its efficacy in reducing the craving for alcohol and mitigating the discomfort associated with withdrawal.
Features
- Contains the active ingredient Acamprosate Calcium equivalent to 333 mg of Acamprosate
- Enteric-coated, delayed-release tablet formulation
- Administered orally three times daily
- Designed for systemic absorption in the gastrointestinal tract
- Manufactured under strict pharmaceutical quality control standards
- Packaged in blister strips to ensure stability and ease of use
Benefits
- Supports long-term abstinence from alcohol by reducing the urge to drink
- Helps restore neurological balance disrupted by chronic alcohol consumption
- Minimizes the physical and psychological discomfort of alcohol withdrawal
- Contributes to improved patient outcomes when combined with counseling
- Non-addictive and does not produce euphoric effects
- May enhance overall quality of life and social functioning
Common use
Acamprol 333 mg is primarily indicated for the maintenance of abstinence in alcohol-dependent patients who have achieved initial detoxification. It is most effective when initiated as soon as possible after the acute withdrawal period and continued throughout the rehabilitation process. The medication is used adjunctively within a broader therapeutic framework that includes behavioral therapy, support groups, and medical supervision. It is not intended for the management of acute alcohol withdrawal symptoms.
Dosage and direction
The recommended dosage of Acamprol for most adult patients is two 333 mg tablets taken three times daily, totaling 1998 mg per day. Tablets should be swallowed whole with water and should not be crushed or chewed. Administration with meals may help reduce potential gastrointestinal discomfort. Dosage adjustments are generally not required for elderly patients, but renal impairment necessitates dosage reduction or discontinuation. Treatment should be continued even during periods of alcohol abstinence, and the duration of therapy is individualized based on patient response and clinical judgment.
Precautions
Patients with severe renal impairment (creatinine clearance ≤30 mL/min) should not use Acamprol. Caution is advised in patients with moderate renal impairment, and dosage adjustment may be necessary. The safety and efficacy in patients under 18 years of age have not been established. Acamprol does not eliminate or reduce withdrawal symptoms, and patients should be monitored for depression or suicidal thoughts. Those with known hypersensitivity to any component of the formulation should avoid this medication.
Contraindications
Acamprol 333 mg is contraindicated in patients with severe renal impairment (creatinine clearance ≤30 mL/min). It is also contraindicated in patients with known hypersensitivity to acamprosate calcium or any excipients in the formulation. The medication should not be used during pregnancy unless clearly necessary, and breastfeeding is not recommended during treatment.
Possible side effect
The most commonly reported adverse reactions include diarrhea, nausea, abdominal pain, and pruritus. Other possible side effects may include headache, dizziness, insomnia, anxiety, and depression. Less frequently, patients may experience vomiting, flatulence, rash, increased libido, or weight changes. These effects are generally mild to moderate and often diminish with continued treatment. Patients should report any persistent or severe symptoms to their healthcare provider.
Drug interaction
No clinically significant pharmacokinetic interactions have been observed with antidepressants, anxiolytics, hypnotics, or other medications commonly used in alcohol dependence treatment. However, Acamprol may potentially interact with drugs that affect renal function. Concurrent use with naltrexone does not appear to affect the pharmacokinetics of either drug. Patients should inform their healthcare provider of all medications, including over-the-counter drugs and herbal supplements.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next scheduled dose. In that case, the missed dose should be skipped, and the regular dosing schedule resumed. Patients should not double the dose to make up for a missed one. Consistent adherence to the prescribed regimen is important for optimal therapeutic effect.
Overdose
Cases of Acamprol overdose have been reported with doses up to 56 grams. Symptoms may include gastrointestinal discomfort, diarrhea, and electrolyte imbalances. Treatment should be supportive and symptomatic, with particular attention to hydration and electrolyte balance. There is no specific antidote for acamprosate overdose. Hemodialysis may be considered in cases of significant overdose, especially in patients with renal impairment.
Storage
Store Acamprol 333 mg tablets at room temperature (15-30°C) in a dry place, protected from light and moisture. Keep the medication in its original packaging until use. Do not store in bathrooms or other areas with high humidity. Keep out of reach of children and pets. Do not use beyond the expiration date printed on the packaging.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Acamprol 333 mg is a prescription medication that should be used only under the supervision of a qualified healthcare professional. Patients should not make any changes to their treatment regimen without consulting their physician. The complete prescribing information should be reviewed before initiating therapy.
Reviews
Clinical trials have demonstrated that Acamprol significantly improves abstinence rates compared to placebo when used as part of a comprehensive treatment program. Many patients report reduced alcohol craving and improved ability to maintain sobriety. Healthcare professionals note that the medication is generally well-tolerated with a favorable safety profile. Long-term studies support its efficacy in supporting sustained recovery from alcohol dependence.