Acivir Pills contain the active ingredient acyclovir, a nucleoside analogue DNA polymerase inhibitor specifically designed to combat viral replication. This oral medication is a first-line treatment for infections caused by the herpes simplex virus (HSV) and varicella-zoster virus (VZV). It works by inhibiting viral DNA synthesis, thereby reducing the severity and duration of outbreaks. Clinically proven and widely prescribed, Acivir offers a reliable therapeutic option for managing both initial and recurrent episodes.

Features

• Active ingredient: Acyclovir 200mg, 400mg, or 800mg per tablet
• Formulation: Film-coated tablets for oral administration
• Mechanism: Selective inhibition of viral DNA polymerase
• Bioavailability: Approximately 15–30%, with dose-proportional pharmacokinetics
• Half-life: 2.5–3.3 hours in adults with normal renal function
• Excretion: Primarily renal, via glomerular filtration and tubular secretion

Benefits

• Reduces healing time for herpes lesions and blisters
• Decreases the frequency of recurrent outbreaks with prophylactic use
• Lowers viral shedding, reducing transmission risk
• Alleviates pain and discomfort associated with active infections
• Minimizes risk of complications in immunocompromised patients
• Supports improved quality of life through effective viral suppression

Common use

Acivir Pills are indicated for the treatment of herpes simplex virus infections, including genital herpes (first episodes and recurrences) and herpes labialis (cold sores). They are also used for the management of herpes zoster (shingles) and for chronic suppressive therapy in patients with frequent recurrences. In immunocompromised individuals, such as those with HIV or undergoing chemotherapy, Acivir is used to prevent severe or disseminated herpes infections.

Dosage and direction

Dosage must be individualized based on indication, renal function, and immune status. For genital herpes: 200 mg five times daily for 10 days (first episode) or 400 mg three times daily for 5 days (recurrence). For suppression: 400 mg twice daily. Herpes zoster: 800 mg five times daily for 7–10 days. Administer with a full glass of water; may be taken with or without food. Dosage adjustment is required in patients with renal impairment (CrCl <50 mL/min). Adhere strictly to prescribed duration; do not discontinue early even if symptoms resolve.

Precautions

Hydrate adequately during treatment to prevent crystalluria and ensure renal protection. Use with caution in elderly patients and those with pre-existing renal impairment—monitor renal function during prolonged therapy. Not recommended during pregnancy unless potential benefit justifies potential risk (Category B). Breastfeeding should be discussed with a healthcare provider due to excretion in milk. Avoid in patients with known hypersensitivity to acyclovir or valacyclovir. Neurological symptoms (e.g., agitation, confusion) may occur, particularly in older adults or those with renal issues.

Contraindications

Hypersensitivity to acyclovir, valacyclovir, or any component of the formulation. Severe renal impairment (CrCl <10 mL/min) without appropriate dose adjustment. Use in neonates and infants under 2 years is not recommended unless under specialist supervision.

Possible side effect

Common: nausea, vomiting, diarrhea, headache. Less common: dizziness, fatigue, skin rash. Rare but serious: acute renal failure, neurological effects (confusion, hallucinations, seizures), thrombocytopenic purpura, hemolytic uremic syndrome. Hepatotoxicity and elevated liver enzymes may occur. Report any signs of hypersensitivity (e.g., angioedema, anaphylaxis) immediately.

Drug interaction

Probenecid may increase acyclovir plasma concentrations by reducing renal clearance. Concurrent use with other nephrotoxic drugs (e.g., aminoglycosides, cyclosporine, NSAIDs) may enhance renal impairment risk. Zidovudine may potentiate lethargy and fatigue. Use caution with drugs that compete for renal tubular secretion.

Missed dose

If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose to catch up. Maintain regular dosing intervals to ensure consistent antiviral activity.

Overdose

Symptoms may include agitation, coma, seizures, and renal impairment. Management is supportive; hemodialysis significantly enhances acyclovir removal. Maintain adequate hydration and monitor renal function closely. Contact a poison control center or seek emergency medical attention immediately.

Storage

Store at room temperature (15–30°C) in a dry place, protected from light and moisture. Keep in the original container, tightly closed. Do not use after the expiration date. Keep out of reach of children and pets.

Disclaimer

This information is for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis, treatment decisions, and personalized dosage recommendations. Do not self-medicate or alter prescribed regimens without medical supervision.

Reviews

“Prescribed Acivir for recurrent genital herpes—noticeably shorter and less severe episodes. Tolerated well with no significant side effects.” – Patient, 34
“As an infectious disease specialist, I find acyclovir to be a cornerstone in herpes management. Acivir is a reliable generic with consistent bioavailability.” – Dr. Elena Rostova, MD
“Effective for shingles pain reduction, though hydration is key to avoiding headache and nausea.” – Patient, 67
“Used as suppressive therapy for years. Quality of life greatly improved with minimal recurrences.” – Patient, 41