Avapro (irbesartan) is an angiotensin II receptor blocker (ARB) prescribed for the management of hypertension. It works by blocking the action of certain natural substances that tighten blood vessels, allowing blood to flow more smoothly and the heart to pump more efficiently. This medication is also indicated for the treatment of diabetic nephropathy in patients with type 2 diabetes and hypertension, offering renal protective benefits. Clinical studies support its efficacy in reducing cardiovascular risk and slowing the progression of kidney disease. Avapro is available in tablet form and is typically taken once daily for consistent 24-hour blood pressure control.

Features

• Active ingredient: Irbesartan
• Drug class: Angiotensin II receptor blocker (ARB)
• Available strengths: 75 mg, 150 mg, 300 mg tablets
• Administration: Oral, once-daily dosing
• Onset of action: Within 1–2 weeks for full antihypertensive effect
• Duration: Provides 24-hour blood pressure control
• Formulation: Film-coated tablets for ease of swallowing
• Prescription status: Requires medical prescription

Benefits

• Effectively lowers high blood pressure, reducing strain on the heart and arteries.
• Decreases the risk of stroke, heart attack, and other cardiovascular complications.
• Provides renal protection in hypertensive patients with type 2 diabetes and nephropathy.
• Offers once-daily dosing for improved adherence and consistent therapeutic coverage.
• Generally well-tolerated with a lower incidence of cough compared to ACE inhibitors.
• Does not usually require routine blood monitoring for potassium or renal function in uncomplicated cases.

Common use

Avapro is primarily used for the treatment of hypertension, either as monotherapy or in combination with other antihypertensive agents. It is also indicated for the management of diabetic nephropathy in patients with type 2 diabetes mellitus and hypertension, demonstrated by the presence of elevated serum creatinine and proteinuria. In clinical practice, it may be used off-label for heart failure management or other conditions where angiotensin II receptor blockade is beneficial, though such use should be guided by a healthcare professional.

Dosage and direction

The recommended initial dose of Avapro for hypertension is 150 mg taken orally once daily. The dosage may be increased to 300 mg once daily if blood pressure remains uncontrolled. For volume-depleted patients, consider starting at 75 mg. For diabetic nephropathy, the target maintenance dose is 300 mg once daily. Avapro may be taken with or without food. Tablets should be swallowed whole with a glass of water; do not crush or chew. Consistency in dosing time is recommended to maintain stable blood levels.

Precautions

Before taking Avapro, inform your healthcare provider if you have a history of kidney disease, liver impairment, heart conditions, or electrolyte imbalances. Avoid use during pregnancy due to potential fetal harm. Hydration status should be monitored, especially in patients on diuretics or with low salt intake. Regular blood pressure checks and periodic renal function and electrolyte assessments are advised. Use caution when driving or operating machinery until the drug’s effects are known, as dizziness may occur.

Contraindications

Avapro is contraindicated in patients with known hypersensitivity to irbesartan or any component of the formulation. Do not use in combination with aliskiren in patients with diabetes. Contraindicated in patients with severe hepatic impairment, biliary obstruction, or in those who are pregnant. Avoid use in patients with hypotension or hemodynamically significant bilateral renal artery stenosis.

Possible side effect

Common side effects may include dizziness, fatigue, musculoskeletal pain, and upper respiratory infection. Less frequently, diarrhea, dyspepsia, heartburn, or mild hyperkalemia may occur. Rare but serious side effects can include angioedema, renal impairment, severe hypotension, and increased serum creatinine. If symptoms such as swelling of the face, lips, or throat; difficulty breathing; or significant lightheadedness occur, seek immediate medical attention.

Drug interaction

Avapro may interact with other medications, including:

• Potassium-sparing diuretics or potassium supplements (increased risk of hyperkalemia)
• NSAIDs (may reduce antihypertensive effect and worsen renal function)
• Lithium (increased lithium levels)
• Other antihypertensive agents (additive blood pressure-lowering effects)
• Aliskiren (avoid concomitant use in diabetic patients)

Always inform your prescriber of all medications, including over-the-counter drugs and supplements.

Missed dose

If a dose of Avapro is missed, take it as soon as remembered the same day. If it is nearly time for the next dose, skip the missed dose and resume the regular schedule. Do not double the dose to make up for a missed one. Consistent daily dosing is important for optimal blood pressure control.

Overdose

Symptoms of Avapro overdose may include severe hypotension, tachycardia, bradycardia, dizziness, and renal failure. Management involves supportive measures, including IV fluids and vasopressors if needed. Hemodialysis is not effective for removing irbesartan due to high protein binding. In case of suspected overdose, seek emergency medical attention or contact a poison control center immediately.

Storage

Store Avapro tablets at room temperature (15–30°C or 59–86°F) in a dry place, protected from light and moisture. Keep the container tightly closed and out of reach of children. Do not use beyond the expiration date printed on the packaging. Dispose of unused medication properly according to local guidelines; do not flush or pour into drains.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

Clinical trials and post-marketing surveillance indicate that Avapro is effective and generally well-tolerated. Many patients report significant improvements in blood pressure control with minimal side effects. Healthcare professionals appreciate its once-daily dosing and renal protective benefits in diabetic patients. Some users note dizziness during the initial treatment phase, which often resolves with continued use. Individual experiences may vary; always follow your healthcare provider’s guidance for optimal results.