Cepmox is a potent third-generation cephalosporin antibiotic designed for the effective treatment of moderate to severe bacterial infections. Combining amoxicillin with a beta-lactamase inhibitor, it offers enhanced coverage against a wide array of Gram-positive and Gram-negative pathogens. Its pharmacokinetic profile ensures high tissue penetration and sustained bactericidal activity, making it a first-line choice in both hospital and outpatient settings. Trusted by clinicians globally, Cepmox delivers reliable microbial eradication with a well-established safety record.

Features

• Contains amoxicillin 500mg and clavulanic acid 125mg per tablet
• Broad-spectrum activity against β-lactamase-producing strains
• Bioavailability of approximately 90% when taken orally
• Rapid onset of action with peak serum concentrations within 1–2 hours
• Stable in gastric acid, allowing for administration without regard to meals
• Available in both oral and intravenous formulations for flexible dosing

Benefits

• Effectively eradicates resistant bacterial strains through beta-lactamase inhibition
• Reduces risk of treatment failure in polymicrobial infections
• Minimizes development of antibiotic resistance with optimized pharmacokinetics
• Supports shorter hospital stays and faster recovery times
• Suitable for pediatric and adult populations with weight-based dosing
• Cost-effective due to high efficacy and reduced need for adjunct therapies

Common use

Cepmox is indicated for the treatment of bacterial infections including community-acquired pneumonia, acute bacterial sinusitis, otitis media, skin and soft tissue infections, urinary tract infections, and intra-abdominal infections. It is also used prophylactically in surgical settings to prevent postoperative infections. Its broad coverage makes it particularly valuable in empiric therapy while awaiting culture and sensitivity results.

Dosage and direction

Adults:
The usual dose is one tablet (amoxicillin 500mg/clavulanic acid 125mg) every 8 hours or one tablet (875mg/125mg) every 12 hours for moderate infections. For severe infections, higher doses or intravenous administration may be required.

Children:
Dosing is based on body weight (25–45 mg/kg/day divided every 8 or 12 hours). Use the suspension formulation for accurate pediatric dosing.

Take with food to minimize gastrointestinal upset. Complete the full course of therapy even if symptoms improve earlier to prevent recurrence and resistance.

Precautions

• Use with caution in patients with hepatic impairment; monitor liver enzymes periodically.
• May cause false-positive glucose reactions in urine with Clinitest®; use glucose oxidase-based tests instead.
• Prolonged use may result in fungal or bacterial superinfection.
• Not recommended during pregnancy unless clearly needed; consult risk-benefit profile.
• Avoid in patients with history of gastrointestinal disease, particularly colitis.

Contraindications

• Hypersensitivity to penicillins, cephalosporins, or any component of the formulation.
• History of cholestatic jaundice or hepatic dysfunction associated with Cepmox.
• Patients with infectious mononucleosis due to increased risk of rash.

Possible side effect

Common side effects include diarrhea, nausea, vomiting, abdominal pain, and skin rash. Less frequently, patients may experience headache, dizziness, vaginitis, or transient elevations in liver enzymes. Serious but rare adverse effects include Clostridium difficile-associated diarrhea, hepatotoxicity, Stevens-Johnson syndrome, and anaphylaxis. Discontinue use and seek medical attention if severe reactions occur.

Drug interaction

• Probenecid may reduce renal tubular secretion of amoxicillin, increasing blood concentrations.
• Concurrent use with oral anticoagulants may enhance anticoagulant effect; monitor INR.
• Bacteriostatic antibiotics (e.g., tetracyclines, macrolides) may reduce bactericidal efficacy.
• Allopurinol may increase incidence of skin rash.
• May reduce efficacy of oral contraceptives; advise alternative contraception during therapy.

Missed dose

If a dose is missed, take it as soon as remembered. However, if it is almost time for the next dose, skip the missed dose and resume the regular schedule. Do not double the dose to catch up.

Overdose

Symptoms may include gastrointestinal distress (nausea, vomiting, diarrhea), electrolyte imbalance, or crystalline. Management is supportive; maintain hydration and electrolyte balance. Hemodialysis may enhance elimination of amoxicillin.

Storage

Store at room temperature (15–30°C) in a dry place. Keep the container tightly closed. For oral suspension, reconstitute with water as directed and store in refrigerator; discard unused portion after 10 days. Keep out of reach of children.

Disclaimer

This information is intended for medical professionals and should not replace clinical judgment. Always confirm indications, contraindications, and dosing based on individual patient factors, local guidelines, and current antimicrobial stewardship principles. Consult prescribing information for full details.

Reviews

“Cepmox has been a cornerstone in our empiric therapy for respiratory infections. Its reliability and broad coverage reduce our need for step-up therapy.” — Dr. Elena Rostova, Infectious Disease Specialist

“As a primary care physician, I appreciate the balance of efficacy and tolerability. Patient compliance is high, and clinical outcomes are consistently positive.” — Dr. Mark Tolbert, General Practitioner

“The pediatric formulation is easy to administer, and dosing flexibility allows for precise treatment in children. A trusted option in my practice.” — Dr. Sofia Jansen, Pediatrician