Desyrel: Restore Restful Sleep and Emotional Balance
| Product dosage: 100mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 60 | $0.81 | $48.30 (0%) | 🛒 Add to cart |
| 90 | $0.69 | $72.45 $62.39 (14%) | 🛒 Add to cart |
| 120 | $0.64 | $96.61 $76.48 (21%) | 🛒 Add to cart |
| 180 | $0.59 | $144.91 $105.66 (27%) | 🛒 Add to cart |
| 270 | $0.55 | $217.36 $147.93 (32%) | 🛒 Add to cart |
| 360 | $0.53
Best per pill | $289.82 $190.19 (34%) | 🛒 Add to cart |
Synonyms | |||
Desyrel (trazodone hydrochloride) is a prescription medication classified as a serotonin antagonist and reuptake inhibitor (SARI). It is primarily indicated for the treatment of major depressive disorder (MDD) in adults, with a well-established efficacy profile. Beyond its antidepressant properties, it is widely utilized off-label for the management of insomnia, particularly due to its sedative effects at lower doses. Its mechanism of action involves modulating neurotransmitters in the brain, specifically by inhibiting the reuptake of serotonin and antagonizing certain serotonin receptors, which contributes to both its antidepressant and sleep-promoting benefits. This dual-action profile makes it a versatile agent in psychiatric and sleep medicine, offering a non-habit forming alternative to traditional sleep aids for many patients.
Features
- Active ingredient: Trazodone hydrochloride
- Available in 50 mg, 100 mg, 150 mg, and 300 mg oral tablets
- Serotonin antagonist and reuptake inhibitor (SARI) class
- FDA-approved for major depressive disorder (MDD)
- Commonly used off-label for insomnia management
- Non-controlled substance with low abuse potential
- Generic versions widely available
- Typically administered once or twice daily
Benefits
- Effectively alleviates symptoms of major depression, including low mood, loss of interest, and fatigue.
- Promotes improved sleep architecture by reducing sleep latency and increasing total sleep time.
- Offers a favorable side effect profile compared to many other antidepressants, particularly regarding sexual dysfunction.
- Provides anxiolytic (anti-anxiety) effects, which can complement its antidepressant and sleep-inducing actions.
- Lower risk of dependence and withdrawal compared to benzodiazepines and Z-drugs when used for insomnia.
- Can be used long-term under medical supervision for chronic depressive or sleep disorders.
Common use
Desyrel is most commonly prescribed for the treatment of major depressive disorder in adults. Its efficacy in improving mood, energy levels, and overall functioning in depressed patients is well-documented. Additionally, it is frequently used off-label to treat insomnia, especially in cases where sleep disturbance is comorbid with depression or anxiety. Clinicians may also prescribe it for generalized anxiety disorder, panic disorder, or as an adjunct in the management of certain pain conditions, such as fibromyalgia or neuropathic pain, though these uses are less evidence-based and considered secondary.
Dosage and direction
The dosage of Desyrel must be individualized based on the patient’s condition, response to therapy, and tolerance. For depression, the initial dose is typically 150 mg per day in divided doses, which may be increased by 50 mg per day every three to four days. The maximum dose for outpatients is usually 400 mg per day, while inpatients may receive up to 600 mg per day in divided doses. For insomnia, lower doses (25–100 mg) are commonly used, usually administered at bedtime. Tablets should be swallowed whole with a sufficient amount of water, and may be taken with or without food to minimize gastrointestinal upset. Dosage adjustments are necessary in elderly patients and those with renal or hepatic impairment.
Precautions
Patients should be monitored for the emergence of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia, hypomania, and mania. Desyrel may impair mental or physical abilities required for performing hazardous tasks, such as operating machinery or driving. Caution is advised in patients with a history of cardiovascular disease, as trazodone has been associated with arrhythmias. Priapism, a prolonged and painful erection, is a rare but serious side effect requiring immediate medical attention. Use with caution in patients with a history of seizures or bipolar disorder. Alcohol should be avoided due to increased risk of sedation and CNS depression.
Contraindications
Desyrel is contraindicated in patients with known hypersensitivity to trazodone hydrochloride or any component of the formulation. Concomitant use with, or within 14 days of stopping, monoamine oxidase inhibitors (MAOIs) is contraindicated due to the risk of serotonin syndrome. It is also contraindicated in patients with a history of priapism. Use is not recommended during the initial recovery phase after myocardial infarction.
Possible side effect
Common side effects include drowsiness, dizziness, fatigue, headache, dry mouth, blurred vision, constipation, and nausea. Less frequently, patients may experience orthostatic hypotension, syncope, confusion, nightmares, weight changes, and nasal congestion. Serious side effects, though rare, include priapism, serotonin syndrome, suicidal thoughts or behaviors (particularly in young adults), QT prolongation, and arrhythmias. Any unusual or severe symptoms should be reported to a healthcare provider immediately.
Drug interaction
Desyrel interacts with several medication classes. Concomitant use with MAOIs, other serotonergic drugs (e.g., SSRIs, SNRIs, triptans, tramadol), may increase the risk of serotonin syndrome. It may potentiate the effects of CNS depressants, including alcohol, benzodiazepines, and opioids. Caution is advised with drugs that prolong the QT interval (e.g., certain antipsychotics, antiarrhythmics). Trazodone is metabolized by CYP3A4; strong inhibitors (e.g., ketoconazole, ritonavir) may increase its levels, while inducers (e.g., carbamazepine, rifampin) may decrease efficacy. Interaction with digoxin or phenytoin may also occur.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is almost time for the next scheduled dose. In that case, the missed dose should be skipped, and the regular dosing schedule resumed. Doubling the dose to make up for a missed one is not recommended, as it may increase the risk of side effects.
Overdose
Symptoms of overdose may include severe drowsiness, vomiting, priapism, respiratory depression, seizures, and cardiac arrhythmias. In cases of suspected overdose, immediate medical attention is critical. Treatment is supportive and symptomatic; there is no specific antidote. Activated charcoal may be administered if ingestion was recent. ECG monitoring is advised due to the risk of QT prolongation.
Storage
Store at room temperature (20–25°C or 68–77°F), in a tightly closed container, away from light, moisture, and heat. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Dispose of unused medication properly via a drug take-back program or according to FDA guidelines.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here.
Reviews
Clinical studies and patient reports generally reflect positive experiences with Desyrel, particularly regarding its efficacy in improving sleep quality and alleviating depressive symptoms. Many users appreciate its non-habit forming nature compared to traditional sleep aids. However, some report side effects such as morning drowsiness or dizziness, which often diminish over time. Individual responses vary, and it is essential to use this medication under close medical supervision to optimize benefits and manage potential adverse effects.