Gyne-Lotrimin is a leading over-the-counter antifungal medication specifically formulated to treat vaginal yeast infections caused by Candida albicans. Its active ingredient, clotrimazole, functions by disrupting the cell membrane of fungal organisms, leading to their eradication. This topical cream provides targeted, localized relief from symptoms such as itching, burning, and discharge, with a treatment regimen designed for convenience and efficacy. Trusted by healthcare professionals and patients alike, Gyne-Lotrimin offers a reliable, accessible solution for uncomplicated vulvovaginal candidiasis.

Features

• Contains 2% clotrimazole as the active antifungal agent
• Available in a smooth, water-miscible cream base for easy application
• Packaged with a measured-dose applicator for hygienic and precise delivery
• Designed for intravaginal use with minimal systemic absorption
• Formulated at pH levels compatible with the vaginal environment
• Sold in 1 oz (28.4 g) tubes, sufficient for full treatment courses

Benefits

• Rapid symptomatic relief, often within just a few days of initiation
• High cure rates demonstrated in clinical studies for uncomplicated infections
• Minimal risk of systemic side effects due to localized action
• Easy-to-use applicator promotes correct dosage and reduces mess
• Available without prescription, allowing prompt self-care initiation
• Prevents recurrence when used as directed for the full treatment period

Common use

Gyne-Lotrimin is indicated for the treatment of vulvovaginal candidiasis. Typical symptoms prompting its use include pruritus, erythema, vulvar swelling, and a thick, white, odorless discharge. It is suitable for immunocompetent, non-pregnant patients aged 12 and older experiencing first-time or occasional yeast infections. Patients with recurrent infections (four or more per year), suspected complicated infection, or who are pregnant should consult a healthcare provider before use.

Dosage and direction

Apply one applicatorful (approximately 5 grams) of Gyne-Lotrimin cream intravaginally once daily, preferably at bedtime, for 3 consecutive days for the standard course. For more persistent symptoms, a 7-day course may be used. Wash hands before and after application. Lie on your back with knees bent, insert the applicator gently into the vagina, and depress the plunger fully. Clean the applicator with mild soap and water after each use. External symptoms may be treated with a small amount of cream applied topically to the vulvar area twice daily, as needed.

Precautions

• For vaginal use only; avoid contact with eyes
• Do not use if allergic to clotrimazole or any other ingredients
• Do not engage in vaginal intercourse during treatment, as this may cause irritation and reduce efficacy
• Not for use in patients with fever, abdominal pain, or foul-smelling discharge (may indicate alternative diagnoses)
• Consult a healthcare provider if symptoms persist after 7 days or recur within 2 months
• Not intended for diabetic patients or those with compromised immune systems without medical supervision

Contraindications

Gyne-Lotrimin is contraindicated in patients with known hypersensitivity to clotrimazole, other imidazoles, or any component of the formulation. It should not be used by individuals with a history of severe local or systemic reactions to antifungal agents. Avoid use in patients with suspected pelvic inflammatory disease, sexually transmitted infections, or non-fungal vaginal pathologies unless properly diagnosed.

Possible side effects

Most patients tolerate Gyne-Lotrimin well. Possible local side effects include mild burning, itching, irritation, or redness at the application site. These are generally transient and resolve with continued use. Rarely, patients may experience skin rash, hives, or swelling. Discontinue use and seek medical attention if severe irritation, blistering, or ulceration occurs. Systemic reactions are exceedingly uncommon due to minimal absorption.

Drug interaction

No significant drug interactions have been reported with topical vaginal clotrimazole. However, concurrent use with other vaginal products (e.g., spermicides, douches) may alter efficacy and is not recommended. Patients using warfarin or similar anticoagulants should monitor for potential enhanced effects, though this interaction is primarily associated with oral azoles. Always inform healthcare providers of all medications and supplements being used.

Missed dose

Apply the missed dose as soon as remembered, unless it is nearly time for the next application. Do not double the dose to catch up. Resume the regular dosing schedule. Consistency is important for eradication of the infection, but a single missed dose is unlikely to significantly impact overall efficacy if the regimen is promptly resumed.

Overdose

Topical overdose is unlikely due to limited systemic absorption. Accidental ingestion may cause gastrointestinal upset (nausea, vomiting). In case of ingestion, seek medical attention or contact a poison control center. Excessive topical application may increase the risk of local adverse effects but is not expected to cause systemic toxicity.

Storage

Store at room temperature (15–30°C or 59–86°F). Do not freeze. Keep the tube tightly closed and away from direct light or excessive moisture. Keep out of reach of children and pets. Discard any unused product after completing the treatment course; do not reuse applicators between episodes.

Disclaimer

This product is for self-treatment of uncomplicated vaginal yeast infections only. Read and follow all label directions. Not for use in patients under 12 years of age without medical advice. If symptoms persist or worsen, or if you experience signs of an allergic reaction, discontinue use and consult a healthcare provider. This information is not exhaustive; always seek the advice of a qualified health professional with any questions regarding a medical condition.

Reviews

Gyne-Lotrimin is consistently highly rated by users for its effectiveness and ease of use. Many report relief from itching and discomfort within 24–48 hours. Clinical studies support its efficacy, with complete resolution of symptoms in the majority of patients following the recommended course. Healthcare professionals often recommend it as a first-line OTC option for uncomplicated yeast infections due to its proven track record and safety profile.