Inderal: Expert Cardiovascular and Neurological Management
| Product dosage: 10mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 90 | $0.51 | $46.10 $46.10 (0%) | 🛒 Add to cart |
| 180 | $0.34 | $92.20 $61.13 (34%) | 🛒 Add to cart |
| 270 | $0.28 | $138.30 $75.16 (46%) | 🛒 Add to cart |
| 360 | $0.26
Best per pill | $184.40 $93.20 (49%) | 🛒 Add to cart |
| Product dosage: 40mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 90 | $0.56 | $50.11 (0%) | 🛒 Add to cart |
| 180 | $0.38 | $100.22 $68.15 (32%) | 🛒 Add to cart |
| 270 | $0.32 | $150.32 $86.19 (43%) | 🛒 Add to cart |
| 360 | $0.29
Best per pill | $200.43 $104.22 (48%) | 🛒 Add to cart |
| Product dosage: 80mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 60 | $0.73 | $44.10 (0%) | 🛒 Add to cart |
| 90 | $0.59 | $66.14 $53.11 (20%) | 🛒 Add to cart |
| 120 | $0.51 | $88.19 $61.13 (31%) | 🛒 Add to cart |
| 180 | $0.44 | $132.29 $79.17 (40%) | 🛒 Add to cart |
| 270 | $0.39 | $198.43 $105.23 (47%) | 🛒 Add to cart |
| 360 | $0.37
Best per pill | $264.57 $132.29 (50%) | 🛒 Add to cart |
Synonyms | |||
Similar products
Inderal (propranolol hydrochloride) is a non-selective beta-blocker medication widely prescribed for the management of hypertension, angina pectoris, certain arrhythmias, migraine prophylaxis, essential tremor, and symptomatic control in hyperthyroidism and anxiety disorders. As a cornerstone in therapeutic regimens, it operates by blocking beta-adrenergic receptors, thereby reducing heart rate, cardiac output, and blood pressure. Its efficacy and well-documented safety profile make it a first-line choice for clinicians aiming to optimize patient outcomes across multiple indications. This comprehensive guide details its pharmacological attributes, clinical applications, and practical considerations for use.
Features
- Active ingredient: Propranolol hydrochloride
- Available formulations: Immediate-release tablets (10 mg, 20 mg, 40 mg, 80 mg), extended-release capsules (60 mg, 80 mg, 120 mg, 160 mg), injectable solution
- Pharmacological class: Non-selective beta-adrenergic blocking agent
- Half-life: Approximately 3–6 hours (immediate-release); 8–11 hours (extended-release)
- Metabolism: Hepatic, primarily via CYP2D6 and CYP1A2 enzymes
- Excretion: Renal
Benefits
- Effectively lowers blood pressure, reducing long-term cardiovascular risk.
- Decreases frequency and severity of angina attacks by reducing myocardial oxygen demand.
- Provides prophylactic management for migraines, diminishing occurrence and intensity.
- Controls symptomatic tremors and situational anxiety through central and peripheral nervous system modulation.
- Stabilizes heart rhythm in tachyarrhythmias by slowing AV nodal conduction.
- Assists in managing thyrotoxicosis symptoms such as palpitations and tremors.
Common use
Inderal is indicated for hypertension, either as monotherapy or in combination with other antihypertensive agents. It is used in the management of angina pectoris to prevent ischemic episodes. For cardiac arrhythmias, particularly supraventricular tachycardias and ventricular tachycardias, it helps stabilize rhythm. It serves as a prophylactic treatment for migraine headaches, reducing attack frequency. Additionally, it is prescribed for essential tremor, hypertrophic subaortic stenosis, pheochromocytoma (in combination with alpha-blockers), and off-label for performance anxiety and akathisia.
Dosage and direction
Dosage must be individualized based on indication, patient response, and tolerability. For hypertension: initial dose is 40 mg twice daily (immediate-release), increasing gradually to 120–240 mg daily in divided doses. Extended-release formulations allow once-daily dosing starting at 80 mg, up to 160 mg daily. For angina:起始剂量为80–320 mg daily in divided doses. Migraine prophylaxis:起始剂量为80 mg daily in divided doses, maintenance may be 160–240 mg daily. For arrhythmias: 10–30 mg three to four times daily before meals and at bedtime. Always titrate gradually; do not abruptly discontinue. Take with food to enhance bioavailability.
Precautions
Use with caution in patients with asthma, COPD, or other bronchospastic diseases due to risk of bronchoconstriction. Monitor heart rate and blood pressure regularly. May mask signs of hypoglycemia in diabetics. Can exacerbate heart failure or conduction disorders. Use cautiously in hepatic impairment; dose adjustment may be necessary. May cause fatigue, dizziness, or depression. Avoid abrupt withdrawal to prevent rebound hypertension or angina. Not recommended during pregnancy unless clearly needed. Elderly patients may require lower doses.
Contraindications
Inderal is contraindicated in patients with sinus bradycardia, heart block greater than first degree, cardiogenic shock, decompensated heart failure, and bronchial asthma. It should not be used in those with hypersensitivity to propranolol or any component of the formulation. Avoid in severe peripheral arterial disease and metabolic acidosis.
Possible side effect
Common side effects include fatigue, dizziness, bradycardia, cold extremities, nausea, and diarrhea. Less frequently, it may cause sleep disturbances, depression, vivid dreams, bronchospasm, hypotension, and erectile dysfunction. Rare but serious adverse effects include heart failure exacerbation, severe bradycardia, AV block, and exacerbation of Raynaud’s phenomenon. Allergic reactions such as rash or pruritus may occur.
Drug interaction
Inderal may interact with calcium channel blockers (e.g., verapamil, diltiazem), increasing risk of bradycardia and heart block. Concomitant use with other antihypertensives may potentiate hypotension. It can mask tachycardia from hypoglycemia when used with insulin or oral hypoglycemics. CYP2D6 inhibitors (e.g., fluoxetine, quinidine) may increase propranolol levels. Avoid with MAO inhibitors due to risk of hypertension. May reduce clearance of lidocaine and theophylline. Use cautiously with digoxin due to additive bradycardic effects.
Missed dose
If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to make up for a missed one. Resume the regular dosing schedule. For extended-release formulations, take the next dose at the usual time.
Overdose
Symptoms of overdose include severe bradycardia, hypotension, heart failure, bronchospasm, hypoglycemia, and seizures. Management involves gastric lavage if recent ingestion, activated charcoal, and supportive measures including atropine for bradycardia, vasopressors for hypotension, glucagon for myocardial depression, and beta-agonists for bronchospasm. Hemodialysis is not effective due to high protein binding.
Storage
Store at room temperature (20–25°C or 68–77°F), away from light and moisture. Keep in the original container, tightly closed. Do not store in the bathroom or near sinks. Keep out of reach of children and pets. Do not use beyond the expiration date.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional for diagnosis, treatment decisions, and personalized medical guidance. Do not initiate or discontinue medication without professional supervision.
Reviews
Clinical studies and meta-analyses consistently support the efficacy and safety of Inderal in managing hypertension, angina, and migraines. Many patients report significant improvement in quality of life, particularly in migraine prophylaxis and essential tremor control. Some note initial side effects like fatigue, which often diminish with continued use. Overall, it remains a trusted option in therapeutic arsenals worldwide.