Lipitor (atorvastatin calcium) is a prescription medication classified as a statin, or HMG-CoA reductase inhibitor, designed to manage high levels of low-density lipoprotein (LDL) cholesterol and triglycerides in the blood. It is widely prescribed to reduce the risk of cardiovascular events, including heart attack and stroke, in adults with risk factors or existing heart conditions. By inhibiting cholesterol production in the liver, Lipitor supports long-term cardiovascular health when used as part of a comprehensive treatment plan under medical supervision.

Features

• Active ingredient: atorvastatin calcium
• Available in tablet strengths: 10 mg, 20 mg, 40 mg, 80 mg
• Formulated for once-daily oral administration
• FDA-approved for use in adults and pediatric patients aged 10 years and older
• Demonstrated efficacy in clinical trials for LDL-C reduction and cardiovascular risk reduction

Benefits

• Significantly lowers LDL (“bad”) cholesterol levels
• Reduces triglycerides and modestly increases HDL (“good”) cholesterol
• Lowers the risk of heart attack, stroke, and revascularization procedures
• Provides cardiovascular protection for patients with type 2 diabetes and other risk factors
• Supports long-term management of atherosclerotic cardiovascular disease (ASCVD)

Common use

Lipitor is commonly prescribed for the treatment of hypercholesterolemia (high cholesterol) and mixed dyslipidemia. It is indicated to reduce the risk of myocardial infarction, stroke, unstable angina, and revascularization in adults with multiple risk factors for heart disease. It may also be used in pediatric patients aged 10 years and older with heterozygous familial hypercholesterolemia.

Dosage and direction

The recommended starting dose is 10 mg or 20 mg once daily. Dosage may be adjusted based on LDL-C response and individual patient factors, with a maximum dose of 80 mg daily. Lipitor may be taken with or without food, at any time of day, though consistency in timing is advised. Dosage adjustments may be necessary for patients taking certain concomitant medications or those with renal impairment.

Precautions

• Liver function tests should be performed before initiating therapy and as clinically indicated
• Patients should report unexplained muscle pain, tenderness, or weakness immediately
• Use with caution in patients who consume substantial quantities of alcohol or have a history of liver disease
• Not recommended during pregnancy or in women who may become pregnant
• May increase HbA1c and fasting serum glucose levels

Contraindications

• Active liver disease or unexplained persistent elevations of hepatic transaminases
• Pregnancy and breastfeeding
• Hypersensitivity to atorvastatin or any component of the formulation
• Concomitant use with strong CYP3A4 inhibitors (e.g., itraconazole, clarithromycin)

Possible side effect

Common side effects may include headache, musculoskeletal pain, diarrhea, and nausea. Less frequently, patients may experience:

• Myalgia (muscle pain)
• Arthralgia (joint pain)
• Insomnia
• Urinary tract infection
• Dyspepsia

Rare but serious side effects include rhabdomyolysis with renal dysfunction, hepatotoxicity, and immune-mediated necrotizing myopathy.

Drug interaction

Lipitor interacts with several medications, including:

• Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole, HIV protease inhibitors)
• Gemfibrozil and other fibrates
• Niacin
• Cyclosporine
• Colchicine
• Oral contraceptives
• Warfarin (monitor INR regularly)

Missed dose

If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose to make up for a missed one. Maintain regular dosing schedule to ensure consistent cholesterol management.

Overdose

There is no specific antidote for atorvastatin overdose. Treatment should be symptomatic and supportive. Liver function and CPK levels should be monitored. Hemodialysis is not expected to significantly enhance elimination.

Storage

Store at room temperature (20-25°C or 68-77°F) in the original container. Protect from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Lipitor is a prescription medication that should be used only under the supervision of a qualified healthcare provider. Individual results may vary. Always follow your healthcare provider’s instructions regarding dosage and administration.

Reviews

“After six months on Lipitor 20 mg, my LDL cholesterol decreased from 190 to 85 mg/dL. No significant side effects experienced aside from occasional mild muscle stiffness.” - John D., 58

“My cardiologist prescribed Lipitor following my heart attack. My lipid profile has improved dramatically, and I feel confident in my ongoing prevention plan.” - Maria L., 64

“Effective for cholesterol management but experienced muscle cramps at the 40 mg dose. Dose reduction to 20 mg maintained efficacy with improved tolerability.” - Robert T., 61