Megalis is a prescription medication containing Tadalafil, a potent PDE5 inhibitor clinically proven to treat erectile dysfunction (ED) in adult men. By enhancing blood flow to the penile tissues during sexual stimulation, it facilitates achieving and maintaining a firm erection sufficient for satisfactory sexual activity. This treatment option offers a reliable, long-acting therapeutic approach, supporting improved sexual performance and overall quality of life for individuals affected by ED.

Features

• Active ingredient: Tadalafil 10mg or 20mg per tablet
• Long duration of action: effects may last up to 36 hours
• Rapid onset: typically begins working within 30 minutes to 1 hour
• Oral administration; film-coated tablet for ease of use
• Manufactured under strict quality control and GMP standards
• Available in blister packs of 4, 8, or 16 tablets

Benefits

• Enables reliable and sustained erectile function with a single dose
• Provides flexibility in timing sexual activity due to extended efficacy window
• Supports improved self-esteem and intimate relationship satisfaction
• Reduces performance anxiety through predictable therapeutic effects
• Non-hormonal mechanism with a well-established safety profile
• May improve symptoms of benign prostatic hyperplasia (BPH) when prescribed accordingly

Common use

Megalis is primarily indicated for the treatment of erectile dysfunction in adult males. It is used on an as-needed basis prior to anticipated sexual activity. Healthcare providers may also prescribe it for daily low-dose administration in certain clinical scenarios, such as for patients who anticipate frequent sexual activity or for concomitant treatment of BPH symptoms. It is not intended for use by women or individuals under 18 years of age.

Dosage and direction

The recommended starting dose for most patients is 10mg taken orally at least 30 minutes before sexual activity. Based on efficacy and tolerability, the dose may be increased to 20mg or decreased to 5mg. Do not take more than one dose in a 24-hour period. For daily use regimens, a typical dose is 2.5mg or 5mg taken at approximately the same time each day, regardless of sexual activity. Megalis may be taken with or without food; however, avoid consuming high-fat meals before administration as this may delay onset of action.

Precautions

• Prior to use, undergo a thorough medical evaluation to assess cardiovascular suitability
• Use with caution in patients with anatomical penile deformity, bleeding disorders, or active peptic ulceration
• May cause hypotension; exercise caution in volume-depleted patients or those on antihypertensive therapy
• Avoid concurrent consumption of grapefruit or grapefruit juice
• Not recommended for patients with severe hepatic impairment (Child-Pugh Class C)
• Priapism (prolonged erection >4 hours) requires immediate medical attention to prevent tissue damage
• Discuss all current medications with your healthcare provider to prevent potential interactions

Contraindications

• Hypersensitivity to Tadalafil or any component of the formulation
• Concurrent use of organic nitrates or nitric oxide donors in any form
• History of non-arteritic anterior ischemic optic neuropathy (NAION)
• Patients with severe cardiovascular instability, including recent myocardial infarction, unstable angina, or life-threatening arrhythmias
• Uncontrolled hypertension (BP >170/100 mmHg) or hypotension (BP <90/50 mmHg)

Possible side effects

Common adverse reactions (≥2%) include:

• Headache
• Dyspepsia
• Back pain
• Myalgia
• Nasal congestion
• Flushing
• Dizziness

Less frequent side effects may include:

• Visual disturbances (blurred vision, cyanopsia)
• Hearing changes or sudden hearing loss
• Gastroesophageal reflux
• Palpitations
• Allergic reactions (rash, urticaria)

Rare but serious adverse events:

• Priapism
• Myocardial infarction
• Stroke
• Severe hypotension
• Seizures

Drug interaction

• Nitrates: Concomitant use is absolutely contraindicated due to risk of severe hypotension
• Alpha-adrenergic blockers: May potentiate hypotensive effects; initiate with caution
• CYP3A4 inhibitors (e.g., ketoconazole, ritonavir): May increase Tadalafil exposure; dose adjustment required
• Antihypertensives: Additive blood pressure-lowering effects possible
• Alcohol: Excessive consumption may increase risk of orthostatic hypotension
• Other PDE5 inhibitors: Concurrent use is not recommended

Missed dose

As Megalis is taken on an as-needed basis, there is no fixed dosing schedule to adhere to. For daily dosing regimens: if a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose to make up for a missed one.

Overdose

Symptoms may include severe headache, dizziness, syncope, prolonged erection, and pronounced hypotension. In case of suspected overdose, seek immediate medical attention. Supportive measures include maintaining supine position and administering intravenous fluids if indicated. Hemodialysis is not expected to significantly enhance elimination due to high protein binding.

Storage

Store at room temperature (15-30°C) in the original packaging, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Properly dispose of any unused or expired medication through take-back programs; do not flush.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Megalis is a prescription medication that should be used only under the supervision of a qualified healthcare professional. Individual results may vary. Always consult with your physician for proper diagnosis and treatment recommendations based on your specific health status and medical history.

Reviews

Clinical studies demonstrate that Tadalafil 20mg significantly improved erectile function in 81% of patients versus 35% with placebo (p<0.001) across multiple randomized controlled trials. Patient-reported outcomes indicate high satisfaction with the duration of action and overall efficacy profile. Real-world evidence supports maintained therapeutic benefit with long-term use when prescribed appropriately.