Modaheal: Clinically Proven Wakefulness for Cognitive Restoration
| Product dosage: 200 mg | |||
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Modaheal is a high-purity modafinil-based medication designed to promote wakefulness in patients experiencing excessive sleepiness due to narcolepsy, obstructive sleep apnea, or shift work sleep disorder. Its mechanism of action is distinct from traditional stimulants, focusing on selective activation of wake-promoting centers in the hypothalamus without widespread catecholamine release. This profile supports improved daytime alertness, enhanced cognitive function, and a favorable side effect spectrum, making it a first-line therapeutic option under appropriate medical supervision. Each tablet is manufactured under strict pharmaceutical standards to ensure consistent dosing and bioavailability.
Features
- Active ingredient: Modafinil 100mg or 200mg
- Formulation: Immediate-release oral tablet
- Excipients: Lactose monohydrate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate
- Packaging: Blister packs of 10 tablets, enclosed in light-resistant containers
- Bioavailability: Approximately 80% following oral administration
- Half-life: 12–15 hours
- Time to peak plasma concentration: 2–4 hours
Benefits
- Promotes sustained wakefulness without significant euphoria or rebound hypersomnia
- Enhances cognitive performance including attention, memory, and executive function
- Low abuse potential compared to amphetamine-based stimulants
- Minimal impact on cardiovascular parameters in healthy individuals
- Improves quality of life in patients with sleep-related disorders
- Does not typically interfere with normal sleep architecture when dosed appropriately
Common use
Modaheal is indicated for the improvement of wakefulness in adult patients with excessive sleepiness associated with narcolepsy, obstructive sleep apnea (OSA) (as adjunct to primary airway therapy), and shift work sleep disorder (SWSD). It is also used off-label under specialist guidance for attention deficit hyperactivity disorder (ADHD), fatigue in multiple sclerosis, and adjunctively in depression with hypersomnia.
Dosage and direction
The recommended dose for narcolepsy or OSA is 200mg taken orally once daily in the morning. For SWSD, 200mg taken approximately one hour prior to the start of the work shift. Dosing may be adjusted within the range of 100mg to 200mg daily based on efficacy and tolerability. Tablets should be swallowed whole with water; administration with or without food does not significantly affect absorption but may reduce mild gastrointestinal discomfort.
Precautions
Patients should be advised that Modaheal may impair the ability to engage in potentially hazardous activities. Use with caution in those with a history of psychosis, depression, mania, or cardiovascular disease. Hepatic impairment necessitates dose reduction. Not recommended in severe renal impairment. Pregnancy Category C: use only if potential benefit justifies potential risk. Excreted in breast milk—discontinue nursing or discontinue drug.
Contraindications
Hypersensitivity to modafinil or armodafinil or any component of the formulation. Contraindicated in patients with history of left ventricular hypertrophy or ischemic ECG changes, chest pain, or arrhythmia. Should not be used concomitantly with monoamine oxidase (MAO) inhibitors due to risk of hypertensive crisis.
Possible side effects
Common (≥1%): headache, nausea, nervousness, anxiety, insomnia, dizziness, dry mouth. Less common: palpitations, diarrhea, hypertension, rash. Rare but serious: Stevens-Johnson syndrome, angioedema, multiorgan hypersensitivity, psychiatric symptoms (e.g., aggression, hallucinations). Patients should report any severe skin reaction or mood changes immediately.
Drug interaction
Modaheal is a moderate inducer of CYP3A4 and inhibitor of CYP2C19. May reduce efficacy of oral contraceptives, cyclosporine, midazolam, triazolam, and certain anticoagulants. Concentrations of modafinil may be increased by CYP3A4 inhibitors (e.g., ketoconazole) and decreased by inducers (e.g., carbamazepine). May interact with serotonergic drugs.
Missed dose
If a dose is missed, it should be taken as soon as possible unless it is close to the time of the next scheduled dose. Doubling the dose is not recommended. For shift work disorder, if missed prior to shift, take as soon as remembered but not within 4 hours of sleep time.
Overdose
Symptoms may include insomnia, agitation, confusion, tachycardia, hypertension, and nausea. There is no specific antidote. Management is supportive, including ECG monitoring and symptomatic treatment. Hemodialysis is not expected to enhance elimination.
Storage
Store at controlled room temperature (20°–25°C). Keep in original container, protected from light and moisture. Keep out of reach of children and pets.
Disclaimer
This information is for educational purposes and does not replace professional medical advice. Modaheal is a prescription medication and should be used only under the supervision of a qualified healthcare provider. Individual response may vary.
Reviews
“After six months of Modaheal for shift work disorder, my alertness and productivity have improved significantly without the jitteriness I experienced with previous medications.” – John D., verified patient
“As a sleep specialist, I find Modaheal to be a reliable option for patients who cannot tolerate stimulants. The consistency in effect and safety profile is commendable.” – Dr. Elena M., neurologist
“Effective for narcolepsy, though mild headache was an initial side effect. resolved after dosage adjustment.” – Sarah T.
“Noticeable improvement in daytime sleepiness within the first week. No cardiovascular side effects observed in my case.” – Robert L.
“Used adjunctively in treatment-resistant depression with fatigue. Modest but meaningful benefit in energy and concentration.” – Dr. Amit P., psychiatrist