Prevacid (lansoprazole) is a proton pump inhibitor (PPI) designed to provide long-lasting control over gastric acid production. It is clinically proven to treat conditions such as gastroesophageal reflux disease (GERD), erosive esophagitis, and Zollinger-Ellison syndrome. By targeting the proton pumps in the stomach lining, Prevacid offers sustained symptomatic relief and promotes healing of acid-damaged esophageal tissue. Available in both prescription and over-the-counter formulations, it remains a trusted option for gastroenterologists and primary care providers seeking effective acid suppression therapy.

Features

• Active ingredient: Lansoprazole 15 mg or 30 mg
• Delayed-release capsules or orally disintegrating tablets
• 24-hour acid control with a single daily dose
• FDA-approved for multiple acid-related indications
• Suitable for short-term and maintenance therapy

Benefits

• Provides rapid and sustained relief from heartburn and acid regurgitation
• Promotes healing of erosive esophagitis and reduces risk of recurrence
• Minimizes nighttime acid breakthrough, improving sleep quality
• Reduces dependency on antacids and H2-receptor antagonists
• Supports mucosal healing in NSAID-associated ulcer risk patients
• May improve overall quality of life for chronic GERD sufferers

Common use

Prevacid is commonly prescribed for the treatment of symptomatic and erosive gastroesophageal reflux disease (GERD), including heartburn and regurgitation. It is also indicated for healing and maintenance of healed erosive esophagitis, treatment of active duodenal ulcers, Helicobacter pylori eradication (in combination with antibiotics), and pathological hypersecretory conditions such as Zollinger-Ellison syndrome. Off-label uses may include prevention of NSAID-induced gastric ulcers and management of upper GI bleeding in critical care settings.

Dosage and direction

The typical adult dosage for GERD is 15‒30 mg once daily for up to 8 weeks. For maintenance of healed erosive esophagitis, 15 mg daily is recommended. H. pylori eradication requires a combination therapy of Prevacid 30 mg twice daily with amoxicillin and clarithromycin for 10‒14 days. Prevacid should be taken before a meal, preferably in the morning. Capsules must be swallowed whole; do not crush or chew. For patients with difficulty swallowing, the capsule may be opened and sprinkled on applesauce or administered via nasogastric tube as directed.

Precautions

Prevacid may mask symptoms of gastric malignancy; appropriate diagnostic evaluation should be conducted if alarm features (e.g., unintentional weight loss, recurrent vomiting, dysphagia) are present. Long-term use (especially beyond one year) may be associated with hypomagnesemia, vitamin B12 deficiency, and increased risk of bone fractures. Use with caution in patients with hepatic impairment. Not recommended during pregnancy unless clearly needed. Avoid in patients with known hypersensitivity to lansoprazole or other PPIs.

Contraindications

Prevacid is contraindicated in patients with a known hypersensitivity to lansoprazole or any component of the formulation. Concomitant use with rilpivirine-containing products is contraindicated due to the potential for decreased antiviral efficacy. Should not be used in patients taking drugs that are dependent on gastric pH for absorption (e.g., atazanavir, erlotinib).

Possible side effect

Common side effects include headache, diarrhea, abdominal pain, and nausea. Less frequently, dizziness, rash, or constipation may occur. Long-term use has been associated with Clostridium difficile-associated diarrhea, acute interstitial nephritis, and subacute cutaneous lupus erythematosus. Hypomagnesemia may manifest as muscle spasms, arrhythmias, or seizures. Vitamin B12 deficiency may occur with prolonged therapy.

Drug interaction

Prevacid may alter the absorption of drugs that require gastric acid for bioavailability, such as ketoconazole, iron salts, and digoxin. It may increase serum levels of methotrexate. Concomitant use with clopidogrel may reduce the antiplatelet effect. May interact with warfarin, requiring closer INR monitoring. Avoid concurrent use with St. John’s wort or rifampin due to reduced lansoprazole efficacy.

Missed dose

If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose to make up for a missed one. Resume the regular dosing schedule. Consistency in daily administration is important for optimal acid control.

Overdose

Limited data exist on lansoprazole overdose. Expected manifestations may include drowsiness, blurred vision, tachycardia, nausea, diaphoresis, flushing, headache, and dry mouth. Management is supportive and symptomatic. Hemodialysis is not likely to be effective due to high protein binding. Contact a poison control center or seek emergency medical attention if suspected.

Storage

Store at room temperature (20‒25°C or 68‒77°F) in a dry place. Keep the bottle tightly closed and protect from moisture and light. Do not store in the bathroom or near sinks. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is intended for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting or changing any medication regimen. Individual patient needs and responses may vary.

Reviews

Clinical studies and patient reports consistently affirm the efficacy of Prevacid in managing acid-related disorders. In a 2020 meta-analysis, lansoprazole demonstrated superior healing rates for erosive esophagitis compared to placebo and non-inferiority to other PPIs. Patient satisfaction surveys note significant improvement in nighttime symptoms and quality of life. Some users report mild and transient side effects, though the majority describe Prevacid as effective and well-tolerated for long-term GERD management.