Pure Ascorbic Acid: Essential Support for Immune Health and Collagen Synthesis
| Product dosage: 60mg | |||
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Synonyms | |||
Ascorbic acid, more commonly known as vitamin C, is a water-soluble micronutrient indispensable for numerous physiological functions. As a potent antioxidant and essential cofactor in enzymatic reactions, it plays a critical role in immune modulation, collagen formation, iron absorption, and neuroprotection. Unlike most mammals, humans cannot synthesize ascorbic acid endogenously due to a mutation in the L-gulono-γ-lactone oxidase (GULO) gene, making adequate dietary or supplemental intake a physiological necessity. This product provides a highly bioavailable, pharmaceutical-grade form of ascorbic acid, designed to support optimal biochemical function and address states of deficiency or increased metabolic demand.
Features
- Pharmaceutical-grade L-ascorbic acid, the biologically active enantiomer
- High-purity, crystalline powder formulation for precise dosing
- Enhanced bioavailability; free from common allergens (gluten, soy, dairy)
- Acid-resistant encapsulation technology to minimize gastric discomfort
- Third-party tested for potency, purity, and heavy metal content
- Manufactured in a cGMP-compliant facility
Benefits
- Potent Antioxidant Activity: Directly scavenges reactive oxygen and nitrogen species, protecting cellular structures from oxidative damage and supporting overall redox balance.
- Immune System Potentiation: Enhances neutrophil phagocytosis and chemotaxis, supports epithelial barrier function, and may reduce the duration and severity of upper respiratory tract infections.
- Essential Cofactor for Collagen Biosynthesis: Serves as an electron donor for prolyl and lysyl hydroxylases, enzymes critical for the stabilization of the collagen triple helix, thereby supporting skin, joint, vascular, and bone integrity.
- Facilitates Non-Heme Iron Absorption: Reduces dietary ferric iron (Fe³⁺) to the more absorbable ferrous form (Fe²⁺) in the duodenum, aiding in the prevention and management of iron-deficiency anemia.
- Neurotransmitter Synthesis: Acts as a cofactor for dopamine β-hydroxylase in the synthesis of norepinephrine and for peptide amidation processes, supporting cognitive function and neurological health.
- Supports Carnitine and Catecholamine Synthesis: Essential for the biosynthesis of L-carnitine, crucial for fatty acid transport into mitochondria for energy production.
Common use
Ascorbic acid supplementation is commonly indicated for the prevention and treatment of scurvy, the classic deficiency disease characterized by fatigue, gingivitis, petechiae, and impaired wound healing. It is widely utilized as adjunctive therapy for general immune support, particularly during periods of physiological stress or seasonal challenges. In clinical practice, it is also employed to enhance iron absorption in patients with iron-deficiency anemia, support collagen repair post-surgery or injury, and as part of antioxidant regimens. Some protocols utilize high-dose intravenous ascorbic acid in oncological supportive care, though oral supplementation is primarily for maintenance and mild deficiency states.
Dosage and direction
The Recommended Dietary Allowance (RDA) for adult men is 90 mg/day and for adult women is 75 mg/day. Smokers are advised to consume an additional 35 mg/day due to increased oxidative stress. For general supplementation, a common dosage ranges from 250 mg to 1000 mg daily, taken in divided doses to maintain plasma saturation and enhance bioavailability.
For the treatment of scurvy, therapeutic doses of 300 mg to 1000 mg daily for at least one week are standard, followed by maintenance at RDA levels.
Direction: Take with a full glass of water. To minimize potential gastrointestinal upset, it is advisable to consume with or immediately after a meal. Do not crush or chew capsules if they are designed for delayed release. For powdered forms, dissolve completely in water or juice.
Precautions
Consult a healthcare provider before use if you have a history of kidney disease, including kidney stones (nephrolithiasis), or hemochromatosis. Due to its modest acidifying effect, high doses may cause gastrointestinal discomfort, including nausea, diarrhea, or abdominal cramps in some individuals; reducing the dose typically alleviates these symptoms. Diabetic patients should note that some testing methods (e.g., certain urine glucose tests) can be interfered with by high levels of ascorbic acid. Long-term consumption of doses significantly exceeding the UL (2000 mg/day for adults) should be undertaken with medical supervision.
Contraindications
Absolute contraindications are rare. However, supplementation is contraindicated in individuals with a known hypersensitivity to ascorbic acid or any component of the formulation. It should be used with extreme caution and under strict medical supervision in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, as very high doses may potentially induce hemolysis. High-dose therapy is generally contraindicated in patients with a history of calcium oxalate kidney stones.
Possible side effect
Ascorbic acid is generally well-tolerated at recommended dosages. The most frequently reported adverse effects are gastrointestinal and are dose-dependent:
- Nausea
- Vomiting
- Heartburn
- Abdominal cramps
- Diarrhea These symptoms are typically transient and resolve upon dose reduction. Other less common effects may include:
- Headache
- Insomnia (particularly with doses taken later in the day)
- Flushing of the skin
Drug interaction
Ascorbic acid can interact with several classes of medications:
- Antacids containing aluminum: Ascorbic acid may increase aluminum absorption; separate administration by at least 2 hours.
- Aspirin and NSAIDs: May increase ascorbic acid excretion, potentially lowering plasma levels.
- Barbiturates and Primidone: May increase the rate of ascorbic acid excretion.
- Chemotherapeutic agents: The antioxidant effects may theoretically interfere with the oxidative mechanisms of some chemotherapies (e.g., alkylating agents, anthracyclines); consultation with an oncologist is imperative.
- Estrogens and Oral Contraceptives: Can increase ascorbic acid levels by decreasing its metabolism.
- Fluphenazine: High doses of ascorbic acid may lower blood levels of fluphenazine.
- Warfarin (Coumadin): Theoretical potential for ascorbic acid to slightly decrease anticoagulant effect, though clinical significance is uncertain; monitor INR closely.
Missed dose
If you miss a dose, take it as soon as you remember. If it is nearly time for the next scheduled dose, skip the missed dose and resume the usual dosing schedule. Do not double the dose to catch up. The regimen can be resumed with the next dose. Consistency is beneficial for maintaining stable plasma levels, but occasional missed doses are not typically concerning given the body’s reservoir capacity.
Overdose
Acute overdose is uncommon due to the efficient renal excretion of excess water-soluble vitamin C. The most likely consequence of a single, very large ingestion (typically >2000-3000 mg at once) is severe gastrointestinal distress, including profuse diarrhea, nausea, and vomiting. Management is supportive and consists of discontinuing the supplement and ensuring hydration. There is no specific antidote. Chronic consumption of doses greatly exceeding the Tolerable Upper Intake Level (UL) may increase the risk of developing calcium oxalate kidney stones in predisposed individuals.
Storage
Store in a cool, dry place at room temperature (15°-30°C or 59°-86°F). Protect from direct light, moisture, and heat. Keep the container tightly closed. Do not store in the bathroom. Keep all dietary supplements out of the reach of children and pets.
Disclaimer
This information is for educational and informational purposes only and is not intended as medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new supplement or health regimen. Never disregard professional medical advice or delay in seeking it because of something you have read here. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Reviews
“As a clinician, I recommend this pharmaceutical-grade ascorbic acid to patients requiring reliable supplementation. Its purity is verified, and the dosing flexibility of the powder form is ideal for titrating to individual tolerance and needs.” – Dr. E. Lawson, MD, Internal Medicine
“I’ve used this product to correct a subclinical deficiency confirmed by blood work. The difference in my energy levels and recovery from minor cuts was noticeable within a few weeks. No GI issues when taken with food.” – Michael T.
“We utilize this in our practice for patients with poor iron absorption. When combined with iron supplements, we observe a marked improvement in ferritin levels over time. A critical tool in nutritional therapy.” – Sarah J., Registered Dietitian
“After a surgery, my surgeon suggested extra vitamin C to aid healing. This was easy to mix into my morning juice. My incisions healed cleanly and quickly, with minimal scarring.” – Linda P.
“The third-party testing and lack of unnecessary additives were the deciding factors for me. It provides exactly what it claims without any fillers. A pure and effective product.” – James K.