Suprax (cefixime) is a third-generation cephalosporin antibiotic designed to target a broad spectrum of bacterial pathogens with high efficacy and a well-established safety profile. It is commonly prescribed for respiratory, urinary tract, and ear infections, offering reliable bactericidal action by inhibiting cell wall synthesis. Its oral bioavailability and once-daily dosing convenience support adherence and clinical success, making it a preferred choice among healthcare providers for both adult and pediatric patients.

Features

• Active ingredient: cefixime
• Available in 400mg tablets and 100mg/5mL oral suspension
• Third-generation cephalosporin antibiotic
• Broad-spectrum activity against Gram-positive and Gram-negative bacteria
• Oral formulation with high bioavailability
• Once-daily dosing regimen for most indications

Benefits

• Effectively eradicates common bacterial pathogens responsible for respiratory, urinary, and ENT infections
• Convenient once-daily dosing improves patient compliance and treatment adherence
• Suitable for both adult and pediatric populations, with a palatable suspension option
• Demonstrates a lower incidence of severe side effects compared to some broader-spectrum alternatives
• Rapid onset of action with measurable clinical improvement often within 48–72 hours
• Reduced risk of resistance development when used appropriately according to susceptibility testing

Common use

Suprax is indicated for the treatment of mild to moderate infections caused by susceptible strains of designated microorganisms. Common uses include acute bacterial exacerbations of chronic bronchitis, otitis media, pharyngitis, tonsillitis, and uncomplicated urinary tract infections. It may also be used off-label for certain sexually transmitted infections, such as uncomplicated gonorrhea, when susceptibility is confirmed.

Dosage and direction

Dosage should be individualized based on infection severity, pathogen susceptibility, and patient factors such as renal function. For most infections in adults and children ≥12 years or ≥50 kg: 400 mg orally once daily, or divided as 200 mg every 12 hours. For pediatric patients 6 months to 12 years: 8 mg/kg/day of the oral suspension, administered once daily or in two divided doses. Treatment duration typically ranges from 7 to 14 days; complete the full course even if symptoms improve earlier.

Precautions

Use with caution in patients with a history of gastrointestinal disease, particularly colitis. Renal impairment may require dosage adjustment; monitor renal function in at-risk populations. Prolonged use may result in fungal or bacterial superinfection. Use in pregnancy only if clearly needed; cefixime crosses the placenta. Exercise caution in breastfeeding women—cefixime is excreted in human milk.

Contraindications

Hypersensitivity to cefixime, any cephalosporin, or any component of the formulation. Contraindicated in patients with a history of severe hypersensitivity reactions (e.g., anaphylaxis) to penicillins or other beta-lactam antibiotics due to potential cross-reactivity.

Possible side effect

Common side effects may include diarrhea, nausea, abdominal pain, headache, and flatulence. Less frequently, dizziness, transient elevations in liver enzymes, or vaginal candidiasis may occur. Serious but rare adverse effects include Clostridioides difficile-associated diarrhea, Stevens-Johnson syndrome, allergic reactions, hematologic effects such as eosinophilia or thrombocytopenia, and interstitial nephritis.

Drug interaction

Probenecid may increase and prolong cefixime blood levels. Concurrent use with carbamazepine may increase carbamazepine levels. Antacids containing aluminum or magnesium may reduce absorption; administer Suprax at least 2 hours before or after such products. Use with caution alongside other nephrotoxic agents. Monitor for potentiated effects with other antibiotics affecting gut flora.

Missed dose

If a dose is missed, take it as soon as remembered unless it is nearly time for the next dose. Do not double the dose to catch up. Resume the regular dosing schedule. Consistent adherence is important to maintain effective drug concentrations and prevent resistance.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric distress, and diarrhea. Management is supportive; gastric lavage may be considered if ingestion was recent. Hemodialysis can remove cefixime from the bloodstream and may be employed in severe cases. There is no specific antidote.

Storage

Store tablets at room temperature (15–30°C), in a tightly closed container, away from moisture and light. Keep the oral suspension refrigerated (2–8°C) and discard any unused portion after 14 days. Keep out of reach of children and pets.

Disclaimer

This information is intended for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis, treatment decisions, and personalized dosage recommendations. Do not self-medicate or alter prescribed regimens without consulting your physician.

Reviews

Clinical studies and post-marketing surveillance indicate high patient satisfaction and efficacy rates with Suprax, particularly regarding its convenience and tolerability. Healthcare providers often note its reliability in treating common community-acquired infections, though emphasis is placed on using it judiciously to curb antibiotic resistance. Some users report gastrointestinal discomfort, but overall adherence remains favorable compared to multi-dose alternatives.