Tetracycline: Broad-Spectrum Antibiotic for Bacterial Infection Control
| Product dosage: 250mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 180 | $0.32 | $57.29 $57.29 (0%) | 🛒 Add to cart |
| 360 | $0.29
Best per pill | $114.58 $104.53 (9%) | 🛒 Add to cart |
| Product dosage: 500mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 60 | $0.72 | $43.22 (0%) | 🛒 Add to cart |
| 90 | $0.64 | $64.83 $57.29 (12%) | 🛒 Add to cart |
| 120 | $0.59 | $86.44 $70.36 (19%) | 🛒 Add to cart |
| 180 | $0.55 | $129.65 $98.50 (24%) | 🛒 Add to cart |
| 270 | $0.52 | $194.48 $139.71 (28%) | 🛒 Add to cart |
| 360 | $0.51
Best per pill | $259.31 $182.92 (29%) | 🛒 Add to cart |
Tetracycline is a time-tested, broad-spectrum antibiotic belonging to the tetracycline class, widely utilized in clinical practice for its efficacy against a diverse range of bacterial pathogens. It functions by inhibiting protein synthesis at the ribosomal level, effectively halting bacterial growth and replication. This mechanism makes it a versatile agent in treating both common and complex infections, from respiratory tract infections to certain sexually transmitted diseases. Its established history, coupled with a well-understood safety profile, positions it as a reliable choice for healthcare providers when indicated.
Features
- Broad-spectrum activity against Gram-positive and Gram-negative bacteria, as well as atypical pathogens
- Available in 250 mg and 500 mg oral capsule formulations
- Demonstrated efficacy against acne vulgaris when used long-term at lower doses
- May be used as part of combination therapy for Helicobacter pylori eradication
- Some formulations are FDA-approved for the treatment of anthrax exposure
Benefits
- Effectively treats a wide variety of bacterial infections, reducing the need for multiple antibiotics
- Helps prevent complications from infections such as pneumonia, Lyme disease, and pelvic inflammatory disease
- Can reduce the severity and frequency of acne breakouts with consistent use
- Offers a cost-effective treatment option compared to newer antibiotics
- Useful in managing certain zoonotic infections and tick-borne illnesses
Common use
Tetracycline is commonly prescribed for bacterial infections including respiratory tract infections (such as pneumonia and bronchitis), skin and soft tissue infections, urinary tract infections, sexually transmitted infections (like chlamydia and gonorrhea), acne vulgaris, Rocky Mountain spotted fever, typhus fever, and as part of combination therapy for H. pylori eradication. It is also used in the management of periodontal disease and as an alternative agent for malaria prophylaxis in certain regions.
Dosage and direction
Dosage varies based on the infection being treated, patient weight, and renal function. For most infections in adults, the typical dose is 250-500 mg orally every 6 hours. For acne vulgaris, lower doses such as 500 mg to 1 gram daily in divided doses are often used. Tetracycline should be taken on an empty stomach, at least 1 hour before or 2 hours after meals, with a full glass of water. Patients should remain upright for at least 30 minutes after administration to reduce the risk of esophageal irritation. Dosage adjustments are necessary in patients with renal impairment.
Precautions
Tetracycline may cause photosensitivity; patients should use sunscreen and protective clothing when outdoors. It should not be used in children under 8 years of age due to the risk of permanent tooth discoloration and enamel hypoplasia. May cause dizziness or lightheadedness; caution should be exercised when driving or operating machinery. Use with caution in patients with hepatic impairment or those taking hepatotoxic drugs. Prolonged use may result in bacterial or fungal overgrowth.
Contraindications
Hypersensitivity to tetracycline or any component of the formulation. Contraindicated in pregnancy due to risk of fetal harm, including inhibition of bone growth and tooth discoloration. Should not be used during breastfeeding as it excretes into breast milk and may affect infant bone and tooth development. Contraindicated in children under 8 years of age. Not recommended for patients with systemic lupus erythematosus due to potential for exacerbation.
Possible side effect
Common side effects include nausea, vomiting, diarrhea, epigastric distress, and glossitis. Photosensitivity reactions may occur. Less frequently, esophagitis and esophageal ulceration have been reported. Rare but serious side effects include pseudotumor cerebri, hepatotoxicity, and blood dyscrasias. Long-term use may lead to development of resistant organisms or superinfection. Discoloration of teeth and enamel hypoplasia may occur if used during tooth development.
Drug interaction
Tetracycline may reduce the effectiveness of oral contraceptives; additional contraceptive methods are recommended. Antacids containing aluminum, calcium, or magnesium, iron preparations, and bismuth subsalicylate can significantly decrease tetracycline absorption. May potentiate the effect of oral anticoagulants. Concurrent use with methoxyflurane may result in fatal renal toxicity. Penicillins may interfere with the bactericidal action of tetracycline. Retinoids may increase the risk of pseudotumor cerebri.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is almost time for the next scheduled dose. In that case, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed one. Maintaining consistent blood levels is important for efficacy, so patients should try to adhere to the prescribed dosing schedule as closely as possible.
Overdose
Symptoms of overdose may include nausea, vomiting, and diarrhea. In severe cases, pancreatitis and hepatitis have been reported. Management is supportive and symptomatic. Gastric lavage may be considered if ingestion was recent. Hemodialysis does not significantly enhance elimination of tetracycline. Patients should seek immediate medical attention if overdose is suspected. There is no specific antidote for tetracycline overdose.
Storage
Store at room temperature between 15-30°C (59-86°F) in a tightly closed container. Protect from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Do not transfer capsules to other containers unless specifically instructed to do so by a pharmacist. Discard any unused medication properly according to local guidelines.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Tetracycline is a prescription medication that should only be used under the supervision of a qualified healthcare professional. The prescribing physician should be consulted for diagnosis and treatment recommendations. Do not self-medicate or share this medication with others. Full prescribing information should be reviewed before use.
Reviews
Clinical studies and decades of use demonstrate tetracycline’s effectiveness in treating susceptible bacterial infections. Many healthcare providers appreciate its broad spectrum of activity and cost-effectiveness. Patients with acne often report significant improvement with long-term use. Some reviews note gastrointestinal side effects as a common reason for discontinuation. The requirement to take on an empty stomach and avoid dairy products is frequently mentioned as a compliance challenge. Overall, it remains a valuable antibiotic when used appropriately for indicated infections.