Alesse is a combination oral contraceptive pill designed to provide effective pregnancy prevention with a low-dose hormonal profile. Each pack contains 21 active tablets of levonorgestrel and ethinyl estradiol, followed by 7 placebo tablets to maintain routine. As a trusted monophasic formulation, it delivers consistent hormone levels throughout the cycle, offering predictability and ease of use. Approved by health authorities, it represents a mainstream option for individuals seeking reversible contraception under medical guidance.

Features

• Contains 0.10 mg levonorgestrel and 0.02 mg ethinyl estradiol per active tablet
• Monophasic formulation ensures uniform hormone delivery
• 28-day cycle pack (21 active + 7 inert tablets)
• Small, easy-to-swallow tablet design
• Hormonally synthetic progestin and estrogen components
• Prescription-only medication requiring healthcare provider consultation

Benefits

• Highly effective at preventing pregnancy when taken correctly, with a typical-use failure rate of approximately 7% and perfect-use rate of over 99%
• May lead to lighter, less painful menstrual periods and reduced menstrual cramps
• Can decrease the risk of developing ovarian cysts and ectopic pregnancies
• Offers non-contraceptive benefits such as potential improvement in acne
• Provides a reversible contraception method that does not interfere with spontaneity
• Contributes to family planning goals with daily routine integration

Common use

Alesse is primarily prescribed for contraception in individuals of reproductive age. It may also be used—under specific medical supervision—to manage moderate acne in those seeking oral contraception, and to regulate menstrual cycles in cases of dysfunctional uterine bleeding. It is not indicated for post-coital or emergency contraception. Use is generally long-term, spanning reproductive years, with periodic reevaluation by a healthcare provider.

Dosage and direction

Take one tablet daily at approximately the same time each day, with or without food. Begin with the first active tablet on the first day of menstruation or the Sunday after menstruation begins, as directed. Follow the order indicated on the blister pack, completing all 21 active tablets before starting the 7 placebo tablets. During the placebo week, withdrawal bleeding typically occurs. Start a new pack the day after finishing the previous pack, regardless of bleeding.

Precautions

• Not suitable for smokers over age 35, due to increased cardiovascular risks
• Regular blood pressure monitoring is advised
• Use with caution in individuals with conditions that may increase susceptibility to fluid retention
• May affect glucose tolerance; diabetic patients should be monitored closely
• Reduced efficacy may occur with gastrointestinal illnesses or concomitant use of certain medications
• Annual gynecological exams are recommended for ongoing users

Contraindications

• History of or current thrombotic disorders (e.g., deep vein thrombosis, pulmonary embolism)
• Cerebrovascular or coronary artery disease
• Known or suspected carcinoma of the breast or estrogen-dependent neoplasia
• Undiagnosed abnormal genital bleeding
• Liver tumors, benign or malignant, or active liver disease
• Known or suspected pregnancy
• Hypersensitivity to any component of the formulation

Possible side effects

Common side effects may include nausea, headache, breast tenderness, and irregular bleeding, especially during the first few cycles. Less frequently, mood changes, weight fluctuation, and decreased libido may occur. Serious but rare adverse effects include venous thromboembolism, stroke, myocardial infarction, and hepatic lesions. Any sudden severe headache, chest pain, visual changes, or leg swelling should prompt immediate medical attention.

Drug interaction

Alesse may interact with drugs that induce hepatic enzymes, such as rifampicin, barbiturates, and certain anticonvulsants, potentially reducing contraceptive efficacy. Broad-spectrum antibiotics like rifampin may also diminish effectiveness. Concurrent use with HIV protease inhibitors or non-nucleoside reverse transcriptase inhibitors may alter hormone levels. Alesse can affect the metabolism of other drugs, including cyclosporine and theophylline.

Missed dose

If one active tablet is missed (less than 24 hours late), take it as soon as remembered and the next dose at the regular time. If two consecutive active tablets are missed in the first two weeks, take two tablets as soon as remembered and two the next day, then resume the regular schedule while using backup contraception for 7 days. If three or more active tablets are missed, discard the pack and begin a new one on the same day, using backup contraception for 7 days. Consult the package insert or a healthcare provider for detailed instructions based on the week of the cycle.

Overdose

Serious ill effects from overdose are not expected, but nausea, vomiting, and withdrawal bleeding may occur. There is no specific antidote; treatment should be symptomatic and supportive. Medical attention is advised, especially in cases of accidental ingestion by children.

Storage

Store at room temperature (15–30°C or 59–86°F) in a dry place, protected from light and moisture. Keep in the original blister pack until use to protect from light. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting, changing, or stopping any medication. Individual medical conditions, risks, and suitability must be evaluated by a physician. Not all uses, precautions, or interactions may be listed here.

Reviews

Clinical studies and user reports generally reflect satisfaction with Alesse for its contraceptive reliability and cycle regulation. Some users note initial side effects such as spotting or nausea, which often subside after several cycles. Healthcare providers frequently recommend it as a well-tolerated, low-dose option for new contraceptive users. Long-term users appreciate its predictability and minimal impact on daily life. As with all hormonal contraceptives, individual experiences vary, and ongoing dialogue with a healthcare provider is essential.