Bupropion SR (sustained-release) is a prescription antidepressant medication belonging to the class of norepinephrine-dopamine reuptake inhibitors (NDRIs). It is specifically formulated to help manage symptoms of major depressive disorder in adults by modulating key neurotransmitters in the brain. Unlike many other antidepressants, Bupropion SR is not associated with weight gain or sexual dysfunction, making it a favorable option for long-term treatment. Its sustained-release mechanism ensures stable plasma concentrations, supporting consistent therapeutic effect with twice-daily dosing.

Features

• Active ingredient: Bupropion Hydrochloride
• Dosage form: Sustained-release oral tablets
• Available strengths: 100 mg, 150 mg, 200 mg
• Mechanism of action: Norepinephrine-dopamine reuptake inhibitor (NDRI)
• Half-life: Approximately 21 hours
• Bioavailability: Not affected by food intake

Benefits

• Reduces symptoms of depression such as low mood, loss of interest, and fatigue
• Minimizes risk of weight gain commonly associated with other antidepressant therapies
• Low incidence of sexual side effects compared to SSRIs and SNRIs
• Sustained-release formulation supports adherence through convenient twice-daily dosing
• May improve concentration and energy levels due to its dopaminergic activity
• Non-sedating profile makes it suitable for daytime use

Common use

Bupropion SR is indicated for the treatment of major depressive disorder (MDD) in adults. It may also be used off-label for seasonal affective disorder (SAD) and as an aid to smoking cessation treatment. Clinical use is based on comprehensive psychiatric assessment and diagnosis, with treatment duration tailored to individual patient response and tolerability.

Dosage and direction

The recommended starting dose is 150 mg once daily in the morning. After three days, the dose may be increased to 150 mg twice daily, with at least 8 hours between doses. The maximum recommended dose is 400 mg per day, given as 200 mg twice daily. Tablets should be swallowed whole and not crushed, chewed, or divided. Dosage adjustments are necessary in patients with hepatic or renal impairment.

Precautions

Patients should be monitored for worsening depression, suicidality, or unusual changes in behavior, especially during initial treatment or dose adjustments. Use with caution in patients with history of seizure disorder, cranial trauma, or eating disorders. May elevate blood pressure—regular monitoring recommended. Avoid abrupt discontinuation; taper dose when discontinuing treatment.

Contraindications

Bupropion SR is contraindicated in patients with seizure disorder or history of seizures. Contraindicated in patients with current or prior diagnosis of bulimia or anorexia nervosa. Should not be used concomitantly with monoamine oxidase inhibitors (MAOIs) or within 14 days of discontinuing MAOI therapy. Hypersensitivity to bupropion or any component of the formulation prohibits use.

Possible side effects

Common side effects (≥1%) include dry mouth, nausea, insomnia, headache, constipation, and dizziness. Less frequent side effects may include tremor, sweating, tinnitus, and blurred vision. Serious side effects requiring immediate medical attention include seizures, allergic reactions, hypertension, hallucinations, and suicidal thoughts.

Drug interaction

Significant interactions occur with MAOIs, increasing risk of hypertensive crisis. May interact with drugs that lower seizure threshold (antipsychotics, antidepressants, systemic corticosteroids). CYP2B6 inhibitors (e.g., ticlopidine, clopidogrel) may increase bupropion exposure. May affect metabolism of drugs metabolized by CYP2D6 (e.g., beta-blockers, SSRIs).

Missed dose

If a dose is missed, take it as soon as remembered unless it is close to the time for the next dose. Do not double the dose to make up for a missed dose. Maintain regular dosing schedule to ensure stable therapeutic levels.

Overdose

Overdose may cause seizures, hallucinations, tachycardia, and loss of consciousness. Medical attention is immediately required. Treatment is symptomatic and supportive; activated charcoal may be administered if presentation is early. No specific antidote exists.

Storage

Store at room temperature (20-25°C or 68-77°F) in a dry place. Protect from light and moisture. Keep in original container with lid tightly closed. Keep out of reach of children and pets.

Disclaimer

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional for diagnosis and treatment recommendations. Do not initiate or discontinue medication without medical supervision.

Reviews

Clinical studies demonstrate Bupropion SR’s efficacy in improving depressive symptoms with favorable tolerability profile. Patient reports frequently note improved energy levels and minimal weight changes compared to other antidepressants. Healthcare providers appreciate its unique mechanism and utility in patients concerned about sexual side effects or weight gain associated with alternative therapies.