Ceftin (cefuroxime axetil) is a second-generation cephalosporin antibiotic designed to combat a wide spectrum of bacterial infections. It works by inhibiting bacterial cell wall synthesis, leading to the eradication of susceptible pathogens. Available in both tablet and oral suspension forms, Ceftin is commonly prescribed for respiratory tract infections, skin infections, Lyme disease, and more. Its broad-spectrum activity and well-established efficacy make it a trusted choice among healthcare providers for treating moderate to severe bacterial conditions.

Features

• Active ingredient: cefuroxime axetil
• Available in 250 mg and 500 mg tablet strengths
• Oral suspension formulation: 125 mg/5 mL and 250 mg/5 mL
• Broad-spectrum activity against Gram-positive and Gram-negative bacteria
• Beta-lactamase stability enhances resistance to enzymatic degradation
• FDA-approved for multiple indications including respiratory and skin infections

Benefits

• Effectively treats bacterial infections such as bronchitis, sinusitis, and pneumonia
• Reduces risk of complications from untreated bacterial conditions
• Convenient twice-daily dosing supports adherence to treatment regimens
• Suitable for both adult and pediatric populations (with adjusted dosing)
• Demonstrates reliable absorption with or without food
• May prevent progression of early Lyme disease when administered promptly

Common use

Ceftin is indicated for the treatment of infections caused by susceptible strains of designated microorganisms. Common uses include acute bacterial exacerbations of chronic bronchitis, secondary bacterial infection of acute bronchitis, pharyngitis/tonsillitis, uncomplicated skin and skin-structure infections, early Lyme disease, and acute bacterial sinusitis. It is also used for uncomplicated urinary tract infections, though this is less frequent. Off-label uses may include otitis media and certain prophylaxis scenarios, per physician discretion.

Dosage and direction

Dosage varies based on infection type, severity, patient age, and renal function. For most adults, the typical dose is 250–500 mg orally twice daily. For more severe infections or those caused by less susceptible organisms, doses may be increased to 500 mg–1 g twice daily. The maximum daily dose is 1,000 mg. Pediatric dosing is weight-based: 20–30 mg/kg/day divided twice daily, not to exceed 1,000 mg daily. Tablets should be swallowed whole; the oral suspension must be shaken well before each use. Administration with food may improve absorption and reduce gastrointestinal upset.

Precautions

Patients should complete the full prescribed course even if symptoms improve earlier to prevent resistance. Use with caution in patients with renal impairment; dosage adjustment is recommended for creatinine clearance below 30 mL/min. May cause Clostridium difficile-associated diarrhea; evaluate if diarrhea occurs during or after treatment. Use in pregnancy only if clearly needed (Category B). Ceftin passes into breast milk; caution is advised during nursing. Avoid in patients with known hypersensitivity to cephalosporins. Monitor for superinfection or fungal overgrowth.

Contraindications

Ceftin is contraindicated in patients with known allergy to cefuroxime, other cephalosporins, or any component of the formulation. Cross-sensitivity with penicillins may occur; avoid in patients with history of severe hypersensitivity (e.g., anaphylaxis) to beta-lactam antibiotics.

Possible side effect

Common side effects include diarrhea, nausea, vomiting, abdominal pain, headache, and dizziness. Less frequently, patients may experience rash, pruritus, vaginitis, transient elevations in liver enzymes, or eosinophilia. Serious but rare adverse effects include pseudomembranous colitis, Stevens-Johnson syndrome, hemolytic anemia, neutropenia, and anaphylaxis. Discontinue and seek medical attention if severe reactions occur.

Drug interaction

Probenecid may inhibit renal excretion of Ceftin, increasing serum levels. Antacids and H2-receptor antagonists can reduce absorption; administer Ceftin at least 2 hours before these agents. May potentiate nephrotoxicity when used with other nephrotoxic drugs (e.g., aminoglycosides, loop diuretics). Use with caution alongside oral anticoagulants due to potential enhancement of anticoagulant effect.

Missed dose

If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to catch up. Resume the regular dosing schedule. Consistent timing helps maintain effective antibiotic concentrations.

Overdose

Symptoms of overdose may include nausea, vomiting, epigastric distress, diarrhea, and convulsions (especially in renal impairment). Treatment is supportive; hemodialysis may enhance elimination of Ceftin. Contact a poison control center or healthcare provider immediately.

Storage

Store tablets at room temperature (15–30°C or 59–86°F) in a tightly closed container. Protect from light and moisture. Reconstituted oral suspension is stable for 10 days at room temperature or under refrigeration; do not freeze. Keep out of reach of children and pets.

Disclaimer

This information is for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis, treatment decisions, and personalized dosing. Do not self-medicate or alter prescribed regimens without guidance.

Reviews

Ceftin is generally well-regarded in clinical practice for its efficacy and tolerability. Healthcare professionals appreciate its broad-spectrum coverage and convenient dosing. Patient reviews often note effectiveness in resolving infections, though some report gastrointestinal side effects. Always discuss individual experiences and concerns with a prescribing physician.