Duratia is a prescription medication specifically formulated for the management of premature ejaculation (PE) in adult men. It contains the active ingredient Dapoxetine, a selective serotonin reuptake inhibitor (SSRI) that is uniquely designed for on-demand use. By increasing serotonin levels in the central nervous system, Duratia helps to delay ejaculation and improve control, thereby enhancing sexual satisfaction for both partners. It represents a clinically validated, non-surgical option for a condition that affects a significant portion of the male population, offering a reliable and effective solution backed by rigorous pharmaceutical research.

Features

• Active ingredient: Dapoxetine hydrochloride
• Available in 30 mg and 60 mg film-coated tablets
• Rapid onset of action; designed for use approximately 1–3 hours before anticipated sexual activity
• Short half-life of approximately 1.5–2 hours, minimizing long-term systemic exposure
• Manufactured under strict GMP (Good Manufacturing Practice) standards
• Requires a valid prescription from a licensed healthcare provider

Benefits

• Significantly increases intravaginal ejaculatory latency time (IELT)
• Improves perceived control over ejaculation
• Enhances sexual satisfaction for both the patient and their partner
• Reduces personal distress and interpersonal difficulty related to premature ejaculation
• On-demand dosing allows for flexibility and spontaneity
• Well-tolerated profile with a low incidence of serious adverse effects when used as directed

Common use

Duratia is indicated for the treatment of premature ejaculation in adult men aged 18–64 years. It is intended for patients who meet the diagnostic criteria for lifelong or acquired PE, characterized by consistent or recurrent ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the person wishes it. This condition must cause marked distress or interpersonal difficulty. It is not intended for use in females, adolescents, or men outside the specified age range. Duratia should be used only when clinically diagnosed premature ejaculation is present and not for occasional instances of rapid ejaculation.

Dosage and direction

The recommended starting dose of Duratia is 30 mg, taken orally with water approximately 1–3 hours before anticipated sexual activity. It may be taken with or without food, although high-fat meals may delay absorption. Based on efficacy and tolerability, the dose may be increased to 60 mg. The maximum recommended dosing frequency is once every 24 hours. Patients should avoid crushing or chewing the tablet. It is essential to follow the prescribing physician’s instructions precisely and not to exceed the recommended dose or frequency. Efficacy is typically observed within a few doses, but consistent use as needed is advised for optimal results.

Precautions

Prior to initiating treatment with Duratia, a thorough medical and psychiatric evaluation should be conducted to rule out other causes of ejaculatory dysfunction. Use with caution in patients with a history of syncope, cardiovascular disease, orthostatic hypotension, or hepatic impairment. Patients should be advised to avoid situations where syncope could lead to injury. Alcohol consumption should be avoided or minimized due to increased risk of adverse effects such as dizziness and hypotension. Duratia is not recommended for use in men with hereditary problems of galactose intolerance, total lactase deficiency, or glucose-galactose malabsorption. Regular follow-up with a healthcare provider is advised to monitor treatment response and tolerability.

Contraindications

Duratia is contraindicated in patients with known hypersensitivity to Dapoxetine or any excipients in the formulation. It must not be used in combination with monoamine oxidase inhibitors (MAOIs), thioridazine, or other SSRIs due to the risk of serotonin syndrome. Concurrent use with potent CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin) is contraindicated. It is also contraindicated in patients with significant hepatic impairment, history of mania or severe depression, and in those with clinically significant heart conditions such as heart failure, conduction abnormalities, or ischemic heart disease.

Possible side effects

The most commonly reported adverse reactions include nausea, dizziness, headache, diarrhea, insomnia, and fatigue. Less frequently, patients may experience syncope, orthostatic hypotension, vomiting, anxiety, blurred vision, and tinnitus. These effects are generally mild to moderate in intensity and often diminish with continued use. Serious but rare side effects may include serotonin syndrome (symptoms include agitation, hallucinations, rapid heart rate, and loss of coordination), prolonged erection, and syncope. Patients should seek immediate medical attention if they experience symptoms of an allergic reaction, such as rash, itching, swelling, severe dizziness, or trouble breathing.

Drug interaction

Duratia has the potential for significant drug interactions. Concomitant use with serotonergic agents (e.g., SSRIs, SNRIs, triptans, tramadol) increases the risk of serotonin syndrome. Potent inhibitors of CYP3A4 (e.g., ketoconazole) and CYP2D6 (e.g., fluoxetine) can increase Dapoxetine plasma concentrations, necessitating dose adjustment or avoidance. Concurrent use with alcohol or other central nervous system depressants may enhance dizziness and sedation. Alpha-blockers and antihypertensives may potentiate orthostatic hypotension. Patients should inform their healthcare provider of all medications, including over-the-counter drugs and herbal supplements, before starting Duratia.

Missed dose

As Duratia is intended for on-demand use rather than daily administration, the concept of a “missed dose” does not apply in the conventional sense. If a patient forgets to take Duratia before sexual activity, it should be taken only if there is sufficient time before anticipated activity (at least 1–3 hours). It should not be taken after sexual activity has begun or to compensate for a missed opportunity. Doubling the dose is not recommended under any circumstances.

Overdose

In case of suspected overdose, immediate medical attention should be sought. Symptoms may include serotonin syndrome (agitation, confusion, tachycardia, hyperthermia), syncope, dizziness, nausea, vomiting, and blurred vision. There is no specific antidote for Dapoxetine overdose; treatment is supportive and symptomatic. Vital signs should be monitored, and ECG may be indicated in cases of significant overdose. Gastric lavage or activated charcoal may be considered if ingestion was recent. Patients should be kept in a supine position to manage orthostatic hypotension.

Storage

Store Duratia tablets at room temperature (15–30°C or 59–86°F), in a dry place, protected from light and moisture. Keep the medication in its original blister pack until use to maintain stability. Do not store in bathrooms or near sinks. Keep out of reach of children and pets. Do not use beyond the expiration date printed on the packaging. Dispose of any unused or expired medication in accordance with local regulations, preferably through a medicine take-back program.

Disclaimer

This information is intended for educational purposes only and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any new medication or making changes to your treatment plan. Do not disregard or delay seeking medical advice based on information provided here. The efficacy and safety of Duratia may vary based on individual health status and compliance with prescribing instructions. The manufacturer and distributors are not liable for any adverse outcomes resulting from the use or misuse of this product.

Reviews

Clinical studies and patient reports indicate that Duratia is effective in prolonging ejaculatory latency and improving control in a majority of users. Many patients report enhanced sexual confidence and relationship satisfaction. Common feedback highlights the convenience of on-demand dosing, though some users note mild side effects such as nausea or dizziness, which often subside with continued use. Overall, it is regarded as a valuable option in the management of premature ejaculation when used under medical supervision.