Hytrin (terazosin hydrochloride) is an alpha-1 adrenergic blocking agent prescribed for the management of hypertension (high blood pressure) and the treatment of symptomatic benign prostatic hyperplasia (BPH). As a selective antagonist of postsynaptic alpha-1 adrenoreceptors, it works by relaxing vascular smooth muscle, leading to vasodilation and reduced peripheral resistance, which effectively lowers blood pressure. For BPH, it relaxes smooth muscle in the prostate and bladder neck, improving urine flow and reducing obstructive symptoms. Its once-daily dosing and proven efficacy make it a trusted option in long-term therapeutic regimens for appropriate patient populations.

Features

• Active ingredient: Terazosin hydrochloride
• Available in tablet form: 1 mg, 2 mg, 5 mg, 10 mg strengths
• Selective alpha-1 adrenergic blocker
• Once-daily oral administration
• FDA-approved for hypertension and symptomatic BPH
• Bioavailability of approximately 90%
• Peak plasma concentration within 1–2 hours
• Half-life of approximately 12 hours

Benefits

• Effectively reduces both systolic and diastolic blood pressure, lowering cardiovascular risk.
• Improves urinary flow rates and reduces symptoms of BPH, such as hesitancy, weak stream, and nocturia.
• Supports once-daily dosing, enhancing patient adherence and convenience.
• Demonstrates a well-established safety profile with extensive clinical use over decades.
• Does not adversely affect blood lipid levels or glucose metabolism.
• May be used as monotherapy or in combination with other antihypertensive agents.

Common use

Hytrin is commonly prescribed for the management of essential hypertension. It is also indicated for the treatment of signs and symptoms of benign prostatic hyperplasia. In clinical practice, it may be used off-label in certain cases of urinary retention or in combination therapies for resistant hypertension, under specialist supervision.

Dosage and direction

For hypertension: Initial dose is 1 mg at bedtime. Dosage may be gradually increased to achieve desired blood pressure response. Common maintenance dose is 2–10 mg once daily. Maximum recommended dose is 20 mg per day.
For BPH: Initial dose is 1 mg at bedtime. Dose should be titrated upward to 2 mg, 5 mg, or 10 mg once daily to achieve improved urinary symptoms. Doses over 20 mg do not provide additional benefit.
Always take exactly as prescribed. Tablets may be taken with or without food. Avoid abrupt discontinuation.

Precautions

• Orthostatic hypotension with or without syncope may occur, especially with initial dosing or dose increases. Arise slowly from sitting/lying positions.
• Use with caution in patients with renal impairment; dosage adjustment may be necessary.
• Priapism (prolonged and painful erection) has been reported; seek immediate medical attention if it occurs.
• Inform your physician if you are scheduled for cataract surgery, as intraoperative floppy iris syndrome has been associated with alpha-blockers.
• Dizziness or drowsiness may impair ability to drive or operate machinery.
• Regular monitoring of blood pressure and BPH symptoms is advised.

Contraindications

• Hypersensitivity to terazosin or any component of the formulation.
• Concomitant use with other alpha-adrenergic blocking agents.
• Severe hepatic impairment.
• Not recommended during pregnancy unless potential benefit justifies potential risk; not for use in children.

Possible side effect

Common side effects may include:

• Dizziness
• Headache
• Asthenia (weakness)
• Nasal congestion
• Peripheral edema
• Palpitations
• Nausea
• Somnolence
  Less common but serious side effects:
• Syncope (fainting)
• Significant hypotension
• Priapism
• Vision abnormalities
• Dyspnea

Drug interaction

• Concomitant use with other antihypertensives, diuretics, or PDE5 inhibitors (e.g., sildenafil) may potentiate hypotensive effects.
• NSAIDs and sympathomimetics may reduce the antihypertensive efficacy of Hytrin.
• Use with caution with CYP3A4 inhibitors (e.g., ketoconazole), which may increase terazosin concentrations.
• Alcohol may enhance orthostatic hypotension and dizziness.

Missed dose

If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to catch up. Resume the regular dosing schedule.

Overdose

Symptoms may include severe hypotension, dizziness, palpitations, shock, or syncope. Management involves cardiovascular support, placing patient in supine position, and administering IV fluids or vasopressors as needed. Seek immediate medical assistance.

Storage

Store at room temperature (15–30°C or 59–86°F). Protect from light and moisture. Keep out of reach of children. Do not use after the expiration date printed on the packaging.

Disclaimer

This information is for educational purposes and does not replace professional medical advice. Always consult a healthcare provider for diagnosis, treatment decisions, and personalized dosage guidance. Do not initiate or discontinue medication without consulting your physician.

Reviews

“After starting Hytrin for my BPH, I noticed a significant improvement in urinary flow within a few weeks. The initial dizziness was manageable by taking it at bedtime.” – Patient, 68
“As a cardiologist, I find Hytrin effective for patients with hypertension who need additional vasodilation. Its once-daily regimen supports long-term adherence.” – Dr. Evans, MD
“While effective, the side effect of nasal congestion was bothersome for me. My doctor adjusted the dose and it became tolerable.” – Patient, 61
“Hytrin remains a solid choice for alpha-blocker therapy, especially in patients with concomitant hypertension and BPH.” – Urologist, 15 years experience