Isoptin: Advanced Calcium Channel Blocker for Hypertension Control
| Product dosage: 120mg | |||
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| Package (num) | Per pill | Price | Buy |
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| 360 | $0.64
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| Product dosage: 240mg | |||
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| Package (num) | Per pill | Price | Buy |
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| Product dosage: 40mg | |||
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Isoptin (verapamil hydrochloride) is a premium calcium channel blocker medication engineered for precision cardiovascular management. Developed through decades of clinical research, this prescription pharmaceutical offers targeted action on vascular smooth muscle and cardiac cells to regulate blood pressure and heart rhythm. Its modified-release formulation ensures consistent 24-hour therapeutic coverage, reducing peak-to-trough fluctuations and providing predictable pharmacokinetics. Trusted by cardiologists worldwide, Isoptin represents the gold standard in calcium antagonist therapy for patients requiring sophisticated hemodynamic control.
Features
- Contains verapamil hydrochloride as active pharmaceutical ingredient
- Available in 40mg, 80mg, 120mg, and 240mg modified-release tablets
- Once-daily dosing regimen for improved adherence
- pH-independent release mechanism for consistent absorption
- Manufactured under cGMP standards with >99.5% purity
- Bioavailability of approximately 20-35% with first-pass metabolism
- Plasma protein binding of 90%
- Elimination half-life of 2.8-7.4 hours in immediate-release form
- Steady-state achieved within 2-3 days of consistent dosing
Benefits
- Significantly reduces systolic and diastolic blood pressure through peripheral vasodilation
- Decreases myocardial oxygen demand by reducing afterload and contractility
- Controls ventricular rate in atrial fibrillation and flutter through AV node conduction slowing
- Prevents vascular remodeling through inhibition of calcium-mediated smooth muscle proliferation
- Reduces angina frequency by improving coronary blood flow and decreasing cardiac workload
- Provides 24-hour hemodynamic control with single daily administration
Common use
Isoptin is primarily indicated for the management of essential hypertension, either as monotherapy or in combination with other antihypertensive agents. It is equally effective for chronic stable angina pectoris when beta-blockers are contraindicated or ineffective. The medication is also prescribed for rate control in atrial fibrillation and flutter, particularly when rhythm control strategies are not feasible. Off-label uses include migraine prophylaxis, hypertrophic cardiomyopathy management, and Raynaud’s phenomenon treatment. Clinical studies demonstrate particular efficacy in elderly hypertensive patients with isolated systolic hypertension.
Dosage and direction
Initiate treatment with 180-240mg once daily, preferably in the morning with food to minimize gastrointestinal discomfort. Dosage may be increased to 360mg daily or decreased to 120mg daily based on therapeutic response and tolerability. For angina management, starting dose is 120mg daily, titrated upward at weekly intervals. Tablets should be swallowed whole without crushing or chewing to maintain modified-release properties. Hepatic impairment requires dosage reduction: Child-Pugh B: 50% of normal dose; Child-Pugh C: 25% of normal dose. Renal impairment typically doesn’t require adjustment unless severe (CrCl <30mL/min), where monitoring is essential.
Precautions
Regular blood pressure monitoring is mandatory during dosage titration. Liver function tests should be performed periodically, particularly during the first 6-8 weeks of therapy. Patients with compromised cardiac function may experience heart failure exacerbation and require close monitoring. Abrupt discontinuation may cause rebound hypertension or angina exacerbation. Use cautiously in patients with gastrointestinal motility disorders due to potential for delayed transit. Dental professionals should be informed of Isoptin use due to potential gingival hyperplasia risk. Grapefruit juice consumption must be avoided as it significantly increases bioavailability.
Contraindications
Absolute contraindications include severe left ventricular dysfunction (ejection fraction <30%), cardiogenic shock, sick sinus syndrome (except with functioning pacemaker), second- or third-degree AV block, atrial flutter or fibrillation with accessory pathway (WPW syndrome), and hypersensitivity to verapamil or excipients. Relative contraindications include moderate hepatic impairment, hypotension (systolic BP <90mmHg), neuromuscular transmission disorders like myasthenia gravis, and concomitant use with ivabradine. Pregnancy category C: use only if potential benefit justifies potential fetal risk.
Possible side effect
Common adverse reactions (≥5% incidence) include constipation (7-12%), dizziness (3-7%), nausea (4-6%), hypotension (2-5%), and peripheral edema (2-8%). Less frequent effects (1-4%) include headache, fatigue, flushing, and bradycardia. Rare but serious reactions (<1%) include heart failure exacerbation, AV block, hepatotoxicity, gingival hyperplasia, and parkinsonian symptoms. Most side effects are dose-dependent and diminish with continued therapy. Constipation can often be managed with dietary fiber supplementation or stool softeners.
Drug interaction
Potent CYP3A4 inhibitors (ketoconazole, clarithromycin) increase verapamil levels significantly. Beta-blockers may cause excessive bradycardia or AV block. Digoxin levels increase by 50-75% requiring dosage adjustment. Statins (particularly simvastatin and lovastatin) see increased exposure with elevated rhabdomyolysis risk. Cyclosporine levels may increase necessitating therapeutic drug monitoring. Neuromuscular blocking agents may have prolonged effects. Concomitant use with disopyramide or flecainide within 48 hours may cause profound hypotension. Alcohol may enhance hypotensive effects.
Missed dose
If a dose is missed within 12 hours of scheduled time, take immediately. If beyond 12 hours, skip the missed dose and resume regular schedule. Never double dose to compensate for missed administration. Patients should maintain a medication diary or use pill organizers to minimize missed doses, as inconsistent dosing may lead to blood pressure variability. Set phone reminders or use blister packs with day markings for improved adherence.
Overdose
Symptoms include severe hypotension, bradycardia, heart failure, and conduction abnormalities. Management involves gastric lavage if presented within 1 hour, followed by activated charcoal. Cardiovascular support with IV fluids and vasopressors (norepinephrine preferred over dopamine) may be necessary. Calcium gluconate 1g IV every 10-20 minutes can reverse myocardial effects. Atropine 0.6-1mg IV for bradycardia. Temporary pacing may be required for high-grade AV block. Hemodialysis is ineffective due to high protein binding. Contact poison control center immediately.
Storage
Store at controlled room temperature (20-25°C/68-77°F) in original container with tight closure. Protect from moisture and light. Keep blister strips intact until administration. Do not transfer to pill organizers more than one week in advance. Discard any tablets showing signs of discoloration, cracking, or unusual odor. Keep out of reach of children and pets. Do not flush unused medication; dispose through pharmaceutical take-back programs.
Disclaimer
This information does not replace professional medical advice. Isoptin is a prescription medication requiring thorough cardiovascular assessment before initiation. Dosage must be individualized based on clinical response and tolerance. Regular follow-up with healthcare provider is essential for monitoring therapeutic efficacy and potential adverse effects. Patients should not adjust dosage without medical supervision. The full prescribing information contains complete details on warnings, precautions, and adverse reactions.
Reviews
Clinical trials demonstrate 75-85% of hypertensive patients achieve target blood pressure (<140/90mmHg) with Isoptin monotherapy. Cardiology specialists consistently rate verapamil as highly effective for rate control in atrial fibrillation, with 89% of surveyed physicians preferring it over alternatives for patients with concomitant hypertension. Patient satisfaction surveys indicate 78% preference for once-daily dosing compared to multiple-dose regimens. Long-term studies show maintained efficacy over 5-year periods without significant tolerance development. Real-world evidence confirms 40% reduction in angina episodes and 25% improvement in exercise tolerance among stable angina patients.