Lotrisone is a prescription topical medication combining two potent active ingredients—clotrimazole, a trusted antifungal agent, and betamethasone dipropionate, a high-potency corticosteroid. This synergistic formulation is specifically designed to treat severe inflammatory fungal skin infections, providing both antifungal action and anti-inflammatory relief. It targets the underlying cause while rapidly alleviating associated symptoms such as redness, itching, and swelling. Clinically proven and dermatologist-recommended, Lotrisone offers a comprehensive approach to managing stubborn dermatomycoses.

Features

• Contains 1% clotrimazole and 0.05% betamethasone dipropionate
• Available in cream and lotion formulations for varied application needs
• Designed for topical use only; not for ophthalmic, oral, or intravaginal use
• White to off-white homogeneous appearance; fragrance-free
• Supplied in 15g and 45g tubes for convenient dosing

Benefits

• Rapidly reduces inflammation, itching, and discomfort associated with fungal infections
• Effectively eradicates dermatophytes such as Trichophyton rubrum and Trichophyton mentagrophytes
• Prevents recurrence by addressing both fungal proliferation and inflammatory response
• Convenient twice-daily application supports treatment adherence
• Suitable for various body regions, including intertriginous areas
• Minimizes risk of secondary bacterial infections through comprehensive symptom control

Common use

Lotrisone is indicated for the topical treatment of tinea pedis (athlete’s foot), tinea cruris (jock itch), and tinea corporis (ringworm) caused by susceptible organisms. It is particularly effective in cases presenting significant inflammation, erythema, or pruritus. The medication may also be used off-label for other corticosteroid-responsive dermatoses complicated by fungal infections, though such use requires careful medical supervision.

Dosage and direction

Apply a thin layer of Lotrisone cream or lotion to the affected area twice daily, in the morning and evening. Gently massage until absorbed. Wash hands thoroughly after application unless treating hands. Treatment duration should not exceed 2 weeks for tinea cruris or tinea corporis, or 4 weeks for tinea pedis, unless directed otherwise by a healthcare provider. Do not cover with occlusive dressings unless specifically instructed.

Precautions

Use only as directed; prolonged application may cause systemic absorption of corticosteroids. Avoid contact with eyes, mucous membranes, and open wounds. Discontinue use if irritation develops. Not recommended for use under diapers or in diaper dermatitis. Use with caution in patients with liver impairment. Monitor for signs of hypothalamic-pituitary-adrenal (HPA) axis suppression with extended use. Pregnancy Category C: use only if potential benefit justifies potential risk.

Contraindications

Hypersensitivity to clotrimazole, betamethasone, other imidazoles, or corticosteroids. Contraindicated in viral skin infections (e.g., herpes simplex, varicella), untreated bacterial or tubercular skin infections, and perioral dermatitis. Not for use in children under 12 years of age.

Possible side effect

Common: burning, itching, irritation, or dryness at application site. Less common: folliculitis, hypertrichosis, hypopigmentation, acneiform eruptions. Rare: allergic contact dermatitis, striae, skin atrophy, telangiectasia. Systemic absorption may rarely cause corticosteroid effects including hyperglycemia, glucosuria, or HPA axis suppression.

Drug interaction

No specific drug interactions have been documented with topical application. However, systemic absorption of corticosteroids may potentially interact with other corticosteroids, diabetes medications, or drugs affecting potassium levels. Inform your physician of all concurrent medications.

Missed dose

Apply as soon as remembered, unless it is nearly time for the next dose. Do not double the dose to make up for a missed application. Maintain regular twice-daily scheduling for optimal efficacy.

Overdose

Topical overdose may lead to systemic corticosteroid effects including Cushing’s syndrome, hyperglycemia, or adrenal suppression. In case of accidental ingestion, seek immediate medical attention. Treatment is supportive and symptomatic.

Storage

Store at room temperature (20-25°C/68-77°F). Do not freeze. Keep tube tightly closed. Protect from light and excessive heat. Keep out of reach of children and pets. Discard any unused product after completion of therapy.

Disclaimer

This information is for educational purposes only and does not replace professional medical advice. Always consult a healthcare provider for diagnosis and appropriate treatment. Use only as prescribed. Do not share medication with others.

Reviews

“Lotrisone provided rapid relief for my severe tinea cruris where antifungals alone had failed. The itching subsided within 24 hours.” — Dermatology patient, 42

“As a practicing dermatologist, I reserve Lotrisone for cases with significant inflammation. It demonstrates excellent efficacy when used appropriately for limited durations.” — Board-certified dermatologist

“Effective but must be used judiciously due to the potent steroid component. Patients should be carefully monitored for adverse effects.” — Clinical pharmacist