Prilox Cream is a clinically-formulated topical treatment designed for the effective management of hemorrhoidal discomfort, itching, and inflammation. Combining the potent vasoconstrictor phenylephrine with the local anesthetic pramoxine, it offers targeted, fast-acting symptomatic relief. This dual-action approach reduces swelling, numbs pain, and soothes irritation, making it a first-line choice for both internal and external hemorrhoid management. Suitable for adult use, it is available over-the-counter, providing accessible and reliable relief from acute hemorrhoidal episodes.

Features

• Contains phenylephrine HCl 0.25% and pramoxine HCl 1%
• Topical emulsion-based formulation for enhanced spreadability and absorption
• Steroid-free composition, minimizing risk of skin thinning with prolonged use
• pH-balanced to match skin physiology, reducing potential for irritation
• Fragrance-free and hypoallergenic, suitable for sensitive skin
• Available in 30g and 60g tubes with hygienic nozzle applicator

Benefits

• Provides rapid relief from pain, burning, and itching within minutes of application
• Reduces swelling and inflammation through localized vasoconstriction
• Soothes irritated perianal tissue, promoting comfort during sitting and bowel movements
• Minimizes risk of secondary infection by reducing scratching and skin breakdown
• Non-greasy, quickly absorbed formula avoids staining clothing or underwear
• Supports healing by alleviating discomfort, allowing normal daily activities to resume

Common use

Prilox Cream is indicated for the temporary relief of discomfort, itching, and swelling associated with internal and external hemorrhoids. It is also used for minor irritations, burning, and pain in the anal and rectal area. Patients often apply it following bowel movements, at bedtime, or as needed for symptomatic control during acute flare-ups. It is not intended for long-term continuous use beyond seven days without medical supervision.

Dosage and direction

Adults and children 12 years and older: After gentle cleansing and drying of the anal area, apply a thin layer of Prilox Cream to the affected area up to 4 times daily, especially after each bowel movement and at bedtime. For internal hemorrhoids, attach the applicator and gently insert into the rectum, then squeeze the tube to deliver the cream. Wash hands before and after application. Do not use for more than 7 days unless directed by a physician. Discontinue use if symptoms persist or worsen.

Precautions

• For external use only; avoid contact with eyes. If contact occurs, rinse thoroughly with water.
• Do not use on broken skin, deep wounds, or infected areas unless directed by a healthcare provider.
• Consult a doctor before use if you have heart disease, high blood pressure, thyroid disorder, diabetes, or difficulty urinating due to prostate enlargement.
• Pregnant or breastfeeding women should use only under medical supervision.
• Discontinue use and seek medical advice if rash, increased irritation, or other unexpected reactions occur.
• Keep out of reach of children.

Contraindications

Prilox Cream is contraindicated in patients with known hypersensitivity to phenylephrine, pramoxine, or any other component of the formulation. It should not be used by individuals with a history of allergic reactions to local anesthetics of the ester or amide type. Avoid use in patients with narrow-angle glaucoma or monoamine oxidase inhibitor (MAOI) therapy within the past 14 days. Not recommended for children under 12 years of age.

Possible side effects

Most patients tolerate Prilox Cream well when used as directed. Possible side effects may include transient burning, stinging, or redness at the application site. Rarely, allergic contact dermatitis, skin dryness, or itching may occur. Systemic absorption is minimal but may theoretically lead to effects such as increased blood pressure, palpitations, dizziness, or tremors, especially with overuse or application to large areas. Discontinue use and consult a healthcare provider if any adverse reactions are noted.

Drug interaction

Although topical absorption is low, phenylephrine may interact with systemic sympathomimetic agents (e.g., decongestants, asthma medications), potentially increasing the risk of cardiovascular effects such as hypertension or tachycardia. Concurrent use with MAOIs or tricyclic antidepressants may enhance pressor effects. Pramoxine has minimal drug interactions but should be used cautiously with other local anesthetics. Always inform your healthcare provider about all medications you are taking, including over-the-counter products.

Missed dose

If a dose is missed, apply Prilox Cream as soon as remembered, unless it is nearly time for the next application. Do not double the dose to make up for a missed one. Resume the regular dosing schedule. Consistent application is ideal for symptom control, but occasional missed doses are unlikely to significantly impact overall efficacy.

Overdose

Topical overdose is unlikely but could occur with excessive application or accidental ingestion. Symptoms may include severe dizziness, headache, rapid heartbeat, hypertension, nervousness, or respiratory depression (if ingested). In case of suspected overdose, remove any remaining product from the skin, and seek immediate medical attention or contact a poison control center. Provide details of the product and amount used.

Storage

Store Prilox Cream at room temperature (15–30°C or 59–86°F). Keep the tube tightly closed and away from direct sunlight, moisture, and heat. Do not freeze. Discard any unused product after the expiration date printed on the packaging. Keep out of reach of children and pets.

Disclaimer

This information is intended for educational purposes only and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider before starting any new medication or if you have questions about a medical condition. Do not disregard or delay seeking professional advice based on content provided here.

Reviews

“As a gastroenterologist, I frequently recommend Prilox Cream for patients experiencing acute hemorrhoidal symptoms. Its combination of vasoconstrictor and anesthetic offers rapid and reliable relief, and patients appreciate the non-greasy texture.” — Dr. Elena Morris, MD

“Suffered from postpartum hemorrhoids and found Prilox Cream incredibly soothing. The itching subsided within minutes, and the swelling reduced noticeably after just two applications. Highly recommend for short-term relief.” — Maria T.

“Effective, but use sparingly. I experienced mild redness after the third day of use, so I switched to every-other-day application with good results. Consult your doctor if you have sensitive skin.” — James L.

“Used as directed after hemorrhoidectomy surgery. Provided excellent pain relief without causing additional irritation. The applicator makes internal application straightforward and hygienic.” — Robert K.