Provera (medroxyprogesterone acetate) is a prescription progestin medication used to treat a variety of hormone-related conditions in women. It is a synthetic form of the natural hormone progesterone and works by adjusting the hormonal balance in the body, addressing issues from abnormal uterine bleeding to amenorrhea and endometriosis. This medication provides a targeted therapeutic approach, helping to manage symptoms and restore regular menstrual cycles under professional medical supervision. Its established efficacy and well-documented profile make it a trusted option in gynecological and endocrine care.

Features

• Active ingredient: Medroxyprogesterone Acetate
• Available in 2.5 mg, 5 mg, and 10 mg oral tablets
• Synthetic progestin with high bioavailability
• FDA-approved for multiple gynecological and hormonal indications
• Typically administered in cyclic or continuous regimens

Benefits

• Effectively treats abnormal uterine bleeding by stabilizing the endometrial lining.
• Helps restore regular menstrual cycles in women with secondary amenorrhea.
• Reduces endometrial hyperplasia risk in postmenopausal women on estrogen therapy.
• Manages pain and symptoms associated with endometriosis.
• Provides a hormone-regulating option for certain cases of infertility workup.
• Can be used as part of hormone replacement therapy (HRT) for balanced estrogen-progestin effects.

Common use

Provera is commonly prescribed for the treatment of secondary amenorrhea (absence of menstrual periods in women who have previously had cycles), abnormal uterine bleeding due to hormonal imbalance without organic pathology, and as a protective agent against endometrial hyperplasia in postmenopausal women undergoing estrogen replacement therapy. It is also used off-label in the management of endometriosis-associated pain and in certain fertility protocols. Its primary mechanism involves transforming proliferative endometrium into secretory endometrium, thereby regulating shedding and bleeding.

Dosage and direction

Dosage varies based on indication and patient response. For secondary amenorrhea: 5–10 mg daily for 5–10 days, with withdrawal bleeding expected within 3–7 days after completion. For abnormal uterine bleeding: 5–10 mg daily for 5–10 days, beginning on day 16–21 of the cycle. For endometrial hyperplasia prevention with estrogen therapy: typically 5–10 mg daily for 12–14 consecutive days per month. Administration should be oral, with or without food, preferably at the same time each day. Always follow the specific dosing instructions provided by the prescribing healthcare provider.

Precautions

Patients should undergo a thorough medical evaluation before starting Provera, including a personal and family history of thromboembolic disorders, breast cancer, or liver disease. Use with caution in patients with conditions that may be influenced by fluid retention, such as epilepsy, migraine, asthma, or cardiac or renal dysfunction. Regular monitoring of blood pressure, liver function, and cardiovascular status is advised. Prolonged use may decrease glucose tolerance; diabetic patients should be monitored closely. Not recommended for use during pregnancy.

Contraindications

Provera is contraindicated in patients with known hypersensitivity to medroxyprogesterone acetate or any component of the formulation; known or suspected pregnancy; undiagnosed abnormal genital bleeding; known or suspected hormone-dependent neoplasia (such as breast or genital cancer); active thrombophlebitis or current or past history of thromboembolic disorders; severe hepatic dysfunction or disease; and missed abortion.

Possible side effect

Common side effects may include nausea, bloating, breast tenderness, headache, dizziness, drowsiness, irregular bleeding, spotting, changes in weight or appetite, and fatigue. Less frequently, mood changes, insomnia, acne, hirsutism, alopecia, and changes in libido may occur. Rare but serious side effects include thrombophlebitis, pulmonary embolism, retinal thrombosis, optic neuritis, and an increased risk of cardiovascular events. Any unusual symptoms should be reported to a healthcare provider promptly.

Drug interaction

Provera may interact with medications such as aminoglutethimide (reduces medroxyprogesterone levels), barbiturates, carbamazepine, phenytoin, rifampin (may increase metabolism and reduce efficacy), and anticoagulants (may alter prothrombin time). Concomitant use with other hormonal therapies may potentiate or antagonize effects. Always inform the prescriber of all medications, including over-the-counter drugs and herbal supplements.

Missed dose

If a dose is missed, it should be taken as soon as remembered unless it is almost time for the next dose. In that case, skip the missed dose and resume the regular schedule. Do not double the dose to make up for a missed one. Consistently missed doses may lead to breakthrough bleeding or reduced efficacy. Consult a healthcare provider for specific guidance based on the treatment regimen.

Overdose

There have been no reports of acute overdose with Provera. However, suspected overdose may manifest as nausea, vomiting, drowsiness, or dizziness. There is no specific antidote; treatment should be symptomatic and supportive. Gastric lavage may be considered if ingestion was recent. Medical attention should be sought immediately in case of suspected overdose.

Storage

Store at room temperature (20–25°C or 68–77°F), in a dry place, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Dispose of unused medication properly according to local guidelines or through a medication take-back program.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or medication. Do not disregard professional medical advice or delay in seeking it because of something you have read here.

Reviews

Clinical studies and patient reports generally reflect Provera’s efficacy in regulating menstrual cycles and managing abnormal uterine bleeding. Many healthcare providers value its predictability and established safety profile when used appropriately. Some patients report satisfactory symptom control, though individual experiences with side effects such as mood changes or weight gain may vary. Long-term user reviews often emphasize the importance of regular follow-up and personalized dosing.