Sarafem is a prescription medication specifically formulated to treat the emotional and physical symptoms of Premenstrual Dysphoric Disorder (PMDD). As a selective serotonin reuptake inhibitor (SSRI), it works by restoring the balance of serotonin in the brain, which can significantly alleviate severe premenstrual symptoms that interfere with daily life. Clinically proven and trusted by healthcare providers, Sarafem offers a targeted approach to managing PMDD, helping patients regain control over their well-being and daily functioning. This medication is intended for use under medical supervision and is part of a comprehensive treatment plan that may include lifestyle adjustments and therapy.

Features

• Contains fluoxetine hydrochloride, a well-established SSRI
• Available in easy-to-swallow capsule form (10 mg and 20 mg strengths)
• Specifically indicated for the treatment of Premenstrual Dysphoric Disorder
• Manufactured under strict quality control standards
• Requires a prescription to ensure appropriate use

Benefits

• Reduces severe mood swings, irritability, and tension associated with PMDD
• Alleviates physical symptoms such as bloating, breast tenderness, and headaches
• Improves overall daily functioning and quality of life
• Helps restore emotional balance through serotonin modulation
• Supported by extensive clinical research and real-world efficacy

Common use

Sarafem is primarily prescribed for the management of Premenstrual Dysphoric Disorder (PMDD), a severe form of premenstrual syndrome that includes significant emotional and physical symptoms. It is used to treat symptoms such as marked irritability, anxiety, depressed mood, and somatic complaints that occur during the luteal phase of the menstrual cycle. Some healthcare providers may also prescribe it off-label for other conditions, but its primary and FDA-approved use remains focused on PMDD.

Dosage and direction

The typical starting dosage of Sarafem for PMDD is 20 mg taken orally once daily, either continuously or only during the luteal phase of the menstrual cycle (the 14 days before menstruation). Your healthcare provider may adjust the dosage based on your individual response and tolerability, with a maximum recommended dose of 80 mg per day. Take Sarafem with or without food, preferably at the same time each day to maintain consistent blood levels. Do not crush, chew, or break the capsules; swallow them whole with water. Always follow your prescriber’s instructions and do not change your dosage without consulting them.

Precautions

Before taking Sarafem, inform your healthcare provider if you have a history of seizures, liver or kidney disease, diabetes, or bipolar disorder. Use caution when driving or operating machinery until you know how Sarafem affects you, as it may cause dizziness or drowsiness. Avoid alcohol while taking this medication, as it can exacerbate side effects. Sarafem may increase the risk of bleeding; notify your doctor if you experience unusual bruising or bleeding. Regular monitoring may be required to assess your response and adjust treatment as needed.

Contraindications

Sarafem is contraindicated in patients who are taking monoamine oxidase inhibitors (MAOIs) or have taken them within the past 14 days due to the risk of serotonin syndrome. It is also contraindicated in individuals with known hypersensitivity to fluoxetine or any of the inactive ingredients in the formulation. Do not use Sarafem if you are taking pimozide or thioridazine. Patients with uncontrolled narrow-angle glaucoma should avoid this medication.

Possible side effects

Common side effects of Sarafem may include nausea, headache, insomnia, drowsiness, fatigue, dry mouth, sweating, and decreased appetite. Some patients may experience sexual dysfunction, such as decreased libido or delayed orgasm. Less frequently, Sarafem can cause anxiety, nervousness, rash, or weight changes. Serious side effects, though rare, include serotonin syndrome, abnormal bleeding, hyponatremia, manic episodes, and suicidal thoughts or behaviors—especially in young adults. Seek immediate medical attention if you experience symptoms such as agitation, hallucinations, rapid heartbeat, or severe dizziness.

Drug interactions

Sarafem can interact with numerous medications, including other SSRIs, SNRIs, triptans, tramadol, tryptophan, antipsychotics, and certain antidepressants, increasing the risk of serotonin syndrome. It may enhance the effects of warfarin and other anticoagulants, raising bleeding risk. Concurrent use with NSAIDs, aspirin, or other drugs that affect bleeding should be monitored closely. Sarafem can inhibit CYP2D6 enzymes, affecting metabolism of drugs like codeine, tamoxifen, and certain beta-blockers. Always inform your healthcare provider of all medications, supplements, and herbal products you are taking.

Missed dose

If you miss a dose of Sarafem, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you are unsure, contact your healthcare provider or pharmacist for guidance.

Overdose

Symptoms of a Sarafem overdose may include nausea, vomiting, agitation, restlessness, hyperactivity, confusion, seizures, and tachycardia. In severe cases, overdose can lead to serotonin syndrome, coma, or cardiac arrhythmias. If you suspect an overdose, seek emergency medical attention immediately or contact a poison control center. Treatment is supportive and may include activated charcoal, gastric lavage, and monitoring of vital signs.

Storage

Store Sarafem at room temperature (between 20°C and 25°C or 68°F and 77°F), in a tightly closed container, away from light, moisture, and heat. Keep out of reach of children and pets. Do not use Sarafem beyond the expiration date printed on the packaging. Properly discard any unused medication through a drug take-back program or by following FDA-recommended disposal methods.

Disclaimer

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before starting or changing any medication regimen. Do not disregard professional medical advice or delay seeking it based on information provided here. Individual responses to medication may vary.

Reviews

Many patients report significant improvement in PMDD symptoms with Sarafem, noting reduced irritability, better mood stability, and enhanced quality of life. Some users mention initial side effects such as nausea or insomnia that often subside after the first few weeks. A minority of patients may not respond as expected or experience persistent side effects. Overall, clinical studies and patient feedback support its efficacy when used as directed under medical supervision.