Zovirax Cream (acyclovir 5%) is a topical antiviral medication specifically formulated for the management of herpes simplex virus infections. As a nucleoside analogue DNA polymerase inhibitor, it works by interfering with viral replication, thereby reducing the severity and duration of outbreaks. This prescription-strength cream is a frontline therapeutic option recommended by dermatologists and healthcare providers for its targeted action and clinical efficacy in treating recurrent episodes of herpes labialis (cold sores) and limited non-life-threatening cutaneous herpes simplex virus infections in immunocompetent patients. Its mechanism offers a direct pharmacological approach to suppressing viral activity at the site of application.

Features

• Contains 5% acyclovir as the active pharmaceutical ingredient
• Formulated in a white, hydrophilic cream base for optimal skin absorption
• Available in 2g and 5g tubes for convenient dosing
• Requires prescription dispensing in most jurisdictions
• Stable at room temperature; does not require refrigeration after dispensing
• Topical administration minimizes systemic absorption compared to oral formulations

Benefits

• Reduces healing time of herpes simplex lesions when applied early in the outbreak
• Decreases viral shedding, potentially lowering transmission risk during active outbreaks
• Alleviates symptoms including pain, burning, and itching associated with herpetic lesions
• Provides localized treatment with minimal systemic side effects
• Helps prevent the progression of lesions from papular to ulcerative stages
• Supports faster crusting and resolution of vesicles when initiated promptly

Common use

Zovirax Cream is primarily indicated for the treatment of recurrent herpes labialis (cold sores) on the face and lips in immunocompetent adults and children over 12 years of age. It is also used for the management of initial and recurrent cutaneous herpes simplex infections, including genital herpes outbreaks, though systemic therapy may be preferred for extensive genital infections. The cream is most effective when applied at the earliest signs of an outbreak, such as prodromal symptoms including tingling, itching, or burning sensations. Clinical studies demonstrate optimal outcomes when treatment begins during the papule or erythema stage before vesicle formation.

Dosage and direction

Apply Zovirax Cream to cover all lesions adequately, using sufficient quantity to thoroughly moisten the affected areas. For herpes labialis: apply cream 5 times per day at approximately 4-hour intervals for 4 days. Wash hands before and after application to prevent autoinoculation or transmission to other individuals. Therapy should be initiated at the earliest sign or symptom of cold sore development. Do not apply to mucous membranes except under physician supervision. Avoid ocular exposure; if accidental contact occurs, rinse thoroughly with water. Treatment duration typically should not exceed 10 days without medical reevaluation.

Precautions

For external use only. Not for ophthalmic, oral, or intravaginal administration. Use cautiously in patients with compromised skin integrity as increased absorption may occur. Avoid application to extensive areas or under occlusive dressings unless directed by a physician. In immunocompromised patients, monitor for possible resistance development with prolonged use. Patients should be advised that Zovirax Cream may not prevent transmission of herpes to others and appropriate precautions should be maintained during outbreaks. Contact with eyes, nose, and mouth should be avoided unless being treated specifically in those areas under medical guidance.

Contraindications

Zovirax Cream is contraindicated in patients with known hypersensitivity to acyclovir, valacyclovir, or any component of the formulation. Should not be used in patients with demonstrated previous anaphylactic reactions to nucleoside analogues. Not recommended for use on mucous membranes except under specific medical supervision due to potential for increased absorption and irritation. Contraindicated for treatment of disseminated herpes infections or encephalitis, which require systemic antiviral therapy.

Possible side effects

Most side effects are localized and transient. Common reactions include: mild pain, burning, or stinging at application site (approximately 30% of patients); pruritus (5-10%); rash including contact dermatitis (3-5%); skin drying or flaking (2-4%); and erythema (1-3%). Uncommon reactions include: edema, vulvitis, and hypersensitivity reactions. Systemic absorption is minimal with topical application, making systemic side effects rare but may include headache, nausea, or diarrhea in susceptible individuals. Discontinue use and consult healthcare provider if severe reactions occur.

Drug interaction

Formal interaction studies have not been conducted with topical acyclovir due to low systemic absorption. However, theoretical interactions exist with other nephrotoxic drugs in patients with renal impairment if significant systemic absorption occurs. No clinically significant interactions with topical corticosteroids have been observed, though concomitant use should be monitored. When used with other topical products, apply Zovirax Cream first and allow complete absorption before applying additional products to avoid dilution or interference with efficacy.

Missed dose

If a dose is missed, apply as soon as remembered unless it is nearly time for the next scheduled application. Do not double the dose to make up for a missed application. Maintain the regular dosing schedule, applying approximately every 4 hours while awake. The efficacy of treatment depends on consistent application during the waking hours, particularly during the first 48-72 hours of outbreak manifestation.

Overdose

Overdose with topical acyclovir is unlikely due to limited systemic absorption. However, accidental ingestion may occur, particularly in pediatric populations. Symptoms of oral ingestion may include nausea, vomiting, headache, confusion, lethargy, convulsions, and renal impairment. In case of accidental ingestion, seek medical attention immediately. Topical overdose could theoretically cause increased local adverse effects including severe irritation, but would not be expected to cause systemic toxicity. Supportive care should be provided based on symptoms.

Storage

Store at controlled room temperature between 15-25°C (59-77°F). Do not freeze. Keep tube tightly closed when not in use. Protect from excessive heat and direct sunlight. Discard any unused medication 30 days after tube opening. Keep out of reach of children and pets. Do not use after expiration date printed on packaging. Do not transfer cream to other containers as this may compromise stability and sterility.

Disclaimer

This information is provided for educational purposes only and does not constitute medical advice. Zovirax Cream is a prescription medication and should be used only under the supervision of a qualified healthcare professional. Individual results may vary based on timing of initiation, immune status, and other factors. Patients should consult their healthcare provider for diagnosis and appropriate treatment recommendations. Not all uses described may be approved in all jurisdictions.

Reviews

Clinical studies demonstrate that Zovirax Cream reduces healing time by approximately 0.5-1 day compared to placebo when applied early in outbreak. In randomized controlled trials, 53% of patients treated with acyclovir cream experienced prevented lesions versus 30% with vehicle when applied at prodrome stage. Patient-reported outcomes indicate significant reduction in pain intensity and duration. Dermatologists consistently rate acyclovir cream as a first-line topical treatment for recurrent herpes labialis. Long-term safety data support its favorable benefit-risk profile with over 30 years of clinical use experience.